Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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Non-Alcoholic Fatty liver disease (NAFLD) is a complex condition where an excessive amount of fat accumulates in the liver, independently from alcohol consumption. It is currently unclear how and why NAFLD develops, although obesity is a clear risk factor. Improved preclinical models are currently needed so that we can gain a better understanding about the pathophysiology of the disease, and develop more effective treatments. CrownBio has recently presented data on our newly developed NAFLD model, which complements our existing resources and technologies for studying the disease.

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Humans, like all mammals, have two types of fat with completely opposite functions: white, which stores energy and when present in excess is linked with diabetes and obesity; and brown, which produces heat by burning energy and is associated with leanness. Recently, a third type of fat was discovered within white fat, called beige fat. Beige fat cells can quickly convert from an energy storing state to an energy burning state in response to environmental changes. UC San Francisco researchers studying beige fat have described a new strategy to preserve this beneficial tissue.

Human babies are born with brown fat, which they use as a natural defence against the cold. For a long time this...

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September is Childhood Cancer Awareness Month, raising awareness and providing time for discussion on this deadly group of diseases. A newly published set of data, which we expect to be a key talking point among specialists this month, is hoping to help accurately predict how recurrent childhood leukemia is likely to respond to further treatment.

Despite significant progress, cancer remains the leading cause of death by disease among children under the age of 14. It is estimated that every year more than 170,000 children are diagnosed with cancer worldwide, with the majority of them not having access to the modern treatment they need.

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