CVMD

Welcome to CrownBio’s CVMD Blog where we share our thoughts
on the latest trends and hot stories in CVMD

blog.png

Why the Current Excitement over Krill in CVD?

by Judith Gorski PhD, June 15, 2017 at 01:28 PM | Tags

wc-19.jpg

Krill are small crustaceans found in all the world's oceans, which have been harvested as a human and animal food source for many years, recently for use in dietary supplements. A new collaborative study has demonstrated that a novel long-chain (LC) omega-3 rich phospholipid preparation extracted from krill oil can reduce cardiovascular disease risk.

A Translational NHP Platform Evaluated CVD Benefits

The study by Hals et al utilized type 2 diabetic and dyslipidemic monkeys as a translational platform to address the question would an extended treatment duration with a low to moderate dose of a novel LC-omega-3 affect cholesterol levels and be beneficial in reducing cardiovascular risk?

Over a period of 12 weeks, monkeys were given escalating doses of the purified LC omega-3 rich phospholipid preparation. The novel preparation altered blood lipid profiles in a beneficial manner in dyslipidemic, diabetic monkeys without liver or kidney toxicity.

Long-chain omega-3 fatty acids have long been marketed as dietary supplements promising to reduce the risk of cardiovascular disease, cancer, and inflammatory diseases. More recently pharmaceuticals containing EPA and DHA, such as Omacor/Lovaza, have been approved by the FDA for reduction of triglycerides in patients having “very high” (>500mg/dL) plasma triglyceride levels.

Potential Useful Human Therapy to Normalize Dyslipidemia

From a human translation standpoint, this novel preparation, as a single-agent treatment, can be useful as a therapy to normalize dyslipidemia without significant side-effects. Furthermore, it can also be potentially used in combination with current therapies such as statins and PCSK9 inhibitors, thereby expanding the arsenal of drugs to combat dyslipidemia and cardiovascular disease.

Krill may be small and bottom of the food chain but these results are sure to make a big impact.


Author


Related posts

Obesity, Cancer Development, and Immunotherapy Response

How does obesity impact cancer development and immunotherapy response? Find out in our review of cutting-edge combined oncology and metabolic disease studies

Exercise, Liver Cancer, and NAFLD Mortality

Our current understanding of the mechanisms linking obesity and liver cancer is poor. Preclinical research links regular exercise to lowered rates of...

Advances in Type 1 Diabetes Research and Treatment

Review the latest cutting-edge advances in type 1 diabetes including an oral anti-diabetes agent, the artificial pancreas, and precision medicine updates.

CVMD-Poster-.jpg