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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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October 28, 2020 Thermoneutrality and Preclinical Obesity Models Explore how to improve translatability of preclinical obesity research by using murine thermoneutral conditions. LEARN MORE
September 15, 2020 Targeting Peroxisome Proliferator-Activated Receptors for NASH Therapy Review the roles of peroxisome proliferator-activated receptor (PPAR) isotypes in managing hepatic and systemic lipid ... LEARN MORE
September 8, 2020 Targeting the Fibroblast Growth Factor Axis for NASH Therapy Review the roles of members of the FGF19 subclass of fibroblast growth factor (FGF) hormones in NAFLD and NASH, and the ... LEARN MORE
July 30, 2020 Obeticholic Acid: Past, Present, and Future? Review the history of obeticholic acid (OCA) from discovery and proof-of-concept, through clinical trials and approval ... LEARN MORE
March 5, 2020 Comparison Guide: Carbon Tetrachloride Induction and Choline Deficient Diet Models Compare the key features of popular commercial mouse models for accelerated NAFLD and NASH including fibrosis, such as ... LEARN MORE
January 23, 2020 NASH Clinical Update: What to Expect in 2020 Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 ... LEARN MORE
January 17, 2020 The Link Between Diabetes and Kidney Disease Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively impacts renal health, and how diabetic kidney disease can be modeled preclinically. LEARN MORE
October 22, 2019 Dietary Mouse Models of NASH: Comparing the AMLN Diets and the MS-NASH Mouse Compare the key features of commercial dietary mouse models of NASH, including disease induction by the AMLN and GAN ... LEARN MORE
July 30, 2019 The Link Between Diabetes and Cardiovascular Disease Patients with diabetes mellitus (DM) have increased risk of developing cardiovascular disease (CVD) and hypertension. ... LEARN MORE
June 6, 2019 Challenges in Preclinical NASH Modeling Review the current challenges in preclinical NASH drug development in the run-up to International NASH Day. LEARN MORE
June 4, 2019 The Link Between Obesity and Type 2 Diabetes Explore the connections between obesity and type 2 diabetes, and how understanding these links can help improve diabetes research and drug development. LEARN MORE