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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

March 7, 2019 Genetic Abnormality Spectrum in Hematologic Cancers What have we learned about the genetics of hematological cancers, and how can that be modelled for research and drug discovery? LEARN MORE
March 6, 2019 Using Genetic Features to ID and QC Murine Tumor Models Learn how unique genetic events can be used to generate a “genetic fingerprint” to ID and QC murine tumor models. LEARN MORE
March 5, 2019 Recognizing and Profiling T Cell Receptors Learn more about T cell receptors in personalized T cell therapy, including TCR diversity, repertoire, and how TCR are ... LEARN MORE
March 1, 2019 Novel Uses for PDX Models in Preclinical Drug Development Learn how unique PDX models are used to support clinical drug development, discover predictive gene signatures, and for ... LEARN MORE
February 28, 2019 Challenges and Opportunities in Pancreatic Cancer Research Learn more about pancreatic cancer -- its associated risk factors, diagnosis, treatment and outcomes -- and current ... LEARN MORE
February 14, 2019 Designing HSC Humanized Model Efficacy Studies Review some key considerations in humanized model study design for successful preclinical oncology research. LEARN MORE
February 13, 2019 Safety and Efficacy Testing of Anti-Obesity Drugs with NHPs Learn how NHP models provide a more human disease-relevant platform for enhanced preclinical safety and efficacy evaluation of anti-obesity agents. LEARN MORE
February 12, 2019 Targeting the FGF/FGFR Signaling Axis with PDX Models Discover the complex range of FGFR family aberrations in cancer and how PDX models are a powerful tool for assessing ... LEARN MORE
February 7, 2019 CD40: Targeting Co-Stimulatory Pathways for Cancer Immunotherapy Explore the role of CD40 in cancer immunotherapy, including its background, functions, and why combination regimens may ... LEARN MORE
February 6, 2019 Target Engagement Studies with Syngeneic Tumor Models Syngeneic tumor models are a rapid and high-throughput option for novel drug discovery. Here’s how to use them for ... LEARN MORE
February 5, 2019 Beginners Guide to PBMC Humanized Tumor Models Discover PBMC-humanized tumor models for short-term immunotherapy assessment studies. LEARN MORE
January 31, 2019 How to Test Human-Specific Combination Immunotherapies In Vivo Learn how to evaluate combinations of human-specific checkpoint inhibitors in vivo, with double knock-in humanized drug ... LEARN MORE
January 29, 2019 Using Syngeneic Tumor Models for POC Studies Syngeneic tumor models are a predictive, high-throughput option for validating novel therapeutic approaches. Here’s how ... LEARN MORE
January 24, 2019 Imaging Orthotopic Disease Explore how preclinical imaging helps visualize disease grown at depth in an in vivo, orthotopic setting. LEARN MORE
January 22, 2019 Tumor Heterogeneity in Preclinical Oncology Models Real tumors are complex and heterogeneous, which has long frustrated efforts to recapitulate the disease in a ... LEARN MORE