Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

March 22, 2018 Are There Are Five Types of Diabetes? New research suggests that there are five types of diabetes, rather than simply Type 1 or Type 2. Understanding diabetes as a group of five distinct diseases could result in improved diagnosis and more effective, personalized treatment. LEARN MORE
March 19, 2018 Targeting Myeloid Derived Suppressor Cells in Immuno-Oncology Immune checkpoint inhibitors (ICIs) have dramatically changed the therapeutic approach to cancer, with antibodies ... LEARN MORE
March 13, 2018 ICOS: Immunostimulatory or Immunosuppressive Target? The rise of immunotherapy has brought many new targets to the forefront of oncology drug development. One promising new ... LEARN MORE
March 7, 2018 New Technique Opens Novel Approaches to Insulin Resistance A newly-described technique could open multiple lines of investigation into the pathophysiology and treatment of ... LEARN MORE
March 1, 2018 Using T Cells in Immuno-Oncology Immuno-oncology drug development challenges researchers to model the interaction between novel immunotherapy agents, ... LEARN MORE
February 27, 2018 CAR-T Cell Therapy: Use Earlier for Better Results CAR-T cell therapies are still in their infancy as clinical oncology treatments, with the first agent approved just 6 ... LEARN MORE
February 22, 2018 Tumor Infiltrating Lymphocytes: Conflicting Approaches in Immuno-Oncology Today’s new frontier in cancer treatment is in fact a very, very old frontier indeed: tumor infiltrating lymphocytes (TILs). New as they seem, TILs were first observed over 150 years ago by Rudolf Virchow, the father of modern pathology. It was a time when disease was considered to be the result of imbalanced bodily humors and his use of a microscope was a ... LEARN MORE
February 20, 2018 How to Assess CAR-T Cell Therapies Preclinically Chimeric antigen receptor (CAR)-T cell therapies are a new and novel immuno-oncology treatment modality, only recently ... LEARN MORE
February 16, 2018 3 Key Uses for Humanized Mouse Models We’ve been focusing on humanized mouse models recently on our blog, from evolution of immunodeficient host mice through ... LEARN MORE
February 9, 2018 X Chromosome Inactivation: New Hypothesis for Lupus Gender Disparity It’s widely accepted that lupus occurs more often in women than men, with many studies over the years trying to ... LEARN MORE
January 30, 2018 Humanized Mouse Model Head to Head: hPBMC vs hCD34+ The future of cancer treatment is often considered to be combination regimens (dual immunotherapeutics or immuno-oncology + targeted agents), which is driving the need to develop models for the assessment of human-specific agents and combinations prior to clinical trial. LEARN MORE
January 26, 2018 Comparison Guide: huNOG® & huNSG™ Humanized Models Previously our blog posts have reviewed humanized mice, looking at hPBMC vs hCD34+ models, how they differ, and how to ... LEARN MORE
January 5, 2018 2018 Technology Advances – Applying Next Generation Sequencing to Single Cell Analysis It is an axiom in biology that expression of genotype determines phenotype. This means, for the large part, that the ... LEARN MORE
December 19, 2017 2017 Review: Precision Medicine - From Traditional to Tailored Treatment With continued advances in technology, and the increasing focus on individualized therapy, the field of precision ... LEARN MORE
December 14, 2017 2017 Review: The Continued Rise of Immunotherapy We CrownBio blog writers have been tasked with looking back at 2017 and reflecting on this year’s game changers in ... LEARN MORE