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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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February 18, 2020 Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the potential for future clinical use. LEARN MORE
February 13, 2020 Targeting KRAS: Finally Drugging the Undruggable? Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent ... LEARN MORE
February 11, 2020 huPBMC Humanized Mouse Models: De-Risking Graft versus Tumor (GvT) Effects Through a Co-Culture Donor Selection Assay Explore how to use a donor selection assay to limit the chances of graft vs tumor (GvT) effects when using huPBMC ... LEARN MORE
February 7, 2020 Preclinical Biomarker Discovery: Top 17 Questions Review key questions on preclinical biomarker discovery from our recent webinar, answered by Mike Batey. LEARN MORE
February 6, 2020 How to Use Mouse Clinical Trials to Reinterpret Clinical Results Explore how to use mouse clinical trials and analysis by linear mixed models approaches to reinterpret clinical trial ... LEARN MORE
February 4, 2020 How to Quantify Drug Efficacy and Effects in Mouse Clinical Trials Learn how to correctly quantify drug efficacy and effects in mouse clinical trials using a linear mixed models ... LEARN MORE
January 31, 2020 How to Optimize Mouse Clinical Trial Study Design Learn how to optimize mouse clinical trial study design, including choosing how many PDX to use, via a linear mixed models approach. LEARN MORE
January 29, 2020 Mouse Clinical Trial Analysis Explore the current methods of mouse clinical trial analysis, and how these are improved by using a linear mixed models ... LEARN MORE
January 23, 2020 NASH Clinical Update: What to Expect in 2020 Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 ... LEARN MORE
January 22, 2020 Cancer Cell Line Authentication Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays. LEARN MORE
January 17, 2020 The Link Between Diabetes and Kidney Disease Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively impacts renal health, and how diabetic kidney disease can be modeled preclinically. LEARN MORE
January 16, 2020 How Are Organoids Different from 3D Primary Cell Cultures? Explore the key differences between organoids and primary cells grown in 3D, from both healthy tissue and tumors. LEARN MORE
January 9, 2020 How to Use Tumor Organoids for Oncology Drug Screening Review how, and why, to use tumor organoids in in vitro oncology drug screening programs. LEARN MORE
December 3, 2019 Top 12 Questions: Applications of PDXO Review the top 12 questions on PDX-derived organoid (PDXO) utilities from our recent webinar, answered by Dr. Rajendra ... LEARN MORE
November 29, 2019 Patient Tumors, PDX, and PDXO: Model Correlation Q&A At our recent webinar we discussed our innovative PDX-derived organoid (PDXO) in vitro platform. We received many ... LEARN MORE