October 16, 2018
Humanized Mouse Models for Immunotherapy Research
Humanized mouse models simulate real patient responses for the evaluation of immunotherapeutic drug candidates. This supports more translatable preclinical immuno-oncology research with deeper insight into an agent’s likely performance in clinical trials.
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October 11, 2018
Tumor Homograft Model Generation: Dissociated Tumor Cells vs Tumor Fragments
Novel murine immunocompetent models are needed to overcome issues with commonly used syngeneic tumor models and ...
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October 9, 2018
Why PDX Are Needed for Metastatic Breast Cancer Research
Metastatic breast cancer is currently incurable, though preclinical research is ongoing. Generating new therapies for ...
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October 5, 2018
Artificial Intelligence for Life Science Diagnostics
There are multiple forms of artificial intelligence (AI), including deep learning, neural networks, Bayesian networks, ...
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October 3, 2018
Oncolytic Viruses in Cancer Therapy
While viral therapy has existed conceptually for some time, it has only recently gained traction as a promising ...
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September 13, 2018
CAR-T Cell Therapy for Solid Tumors
CAR-T cell therapies are currently only approved for blood cancers, but new preclinical research shows promise in using ...
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September 11, 2018
Using Plasma Ceramides to Predict Coronary Artery Disease
Cardiovascular disease (CVD) is the number one cause of death globally, making improved prognostic disease indicators an urgent priority. Are ceramides a potential biomarker for our risk of CVD and coronary artery disease?
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September 4, 2018
Prostate Cancer Patient-Derived Xenograft (PDX) Models
Clinically-relevant prostate cancer patient-derived xenograft (PDX) models are notoriously hard to generate. Here we ...
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August 31, 2018
Why Are Prostate Cancer Preclinical Models Hard to Develop?
Prostate cancer is a particularly difficult cancer type to model for preclinical research. Why are prostate cancer ...
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August 17, 2018
Facilitating Drug Discovery with 3D In Vitro Oncology Models
Around 95% of new anticancer drugs eventually fail in clinical trials, despite promising results when tested on 2D in ...
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August 7, 2018
Preclinical Research Models of NAFLD/NASH
Most preclinical models of NAFLD/NASH are limited to studying specific aspects of the disease. In this blog post, you can review ideal applications for currently available NAFLD/NASH models and discover a new, more translatable choice for preclinical drug development.
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August 2, 2018
Are Noninvasive Tests Enough for NAFLD/NASH Diagnosis?
There is significant interest in validating strategies for the noninvasive evaluation of fibrosis in NAFLD/NASH. This ...
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July 31, 2018
From Pathogenesis to Treatment with NAFLD/NASH
Non-alcoholic steatohepatitis (NASH) is a hot topic in 2018, with a race to the first approved treatment well under way ...
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July 26, 2018
IDO to I DON’T – IDO1 Inhibitor Development News
As targeted immuno-oncology agents make impressive strides in cancer treatment, researchers are looking for agents that ...
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July 24, 2018
Improving Cardiac Function with FTY720 – ADA 2018
Our ADA presentations this year included a collaborative poster with Pegasus Bio. The studies used our unique panel of ...
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