September 14, 2021
Accelerating Cancer Drug Discovery with Digital Pathology-Based Biomarker Analysis
Digital pathology is an innovative technology that is transforming the field of modern pathology.
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September 1, 2021
In Vitro Potency Assays for Assessing the Function of anti-PD-1 Checkpoint Inhibitors
In this post we explore the different in vitro potency assays for assessing the function of anti-PD-1 checkpoint ...
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August 16, 2021
Next-Generation Sequencing in Cell Line and Biosample Authentication
While the authentication of biosamples (i.e., cell lines, organoids, xenograft and homograft models) has long been ...
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August 2, 2021
In vivo preclinical models for immune-mediated inflammatory disease drug development
In this blog we will explore immune-mediated inflammatory diseases (IMIDs)—which represent a diverse group of ...
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July 5, 2021
Preclinical Models for Bispecific T Cell Engager Development
Last month we hosted a webinar with Dr. Ludovic Bourré, Senior Director of Scientific Engagement at CrownBio, focused ...
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June 1, 2021
Ask the Expert: Organoid and Immune Cell Co-Cultures
Dr Yujun Huang, Senior Director Immuno-Oncology at CrownBio, answers the most popular questions from his recent ...
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May 4, 2021
For the Children: Advancing the Cause of Pediatric Cancer Research
Why are cancer treatments for children lagging behind the latest advancements in clinical oncology? CrownBio Director Mike Batey takes a closer look at pediatric cancer and how recent regulatory changes and additional research focus may deliver new therapies for kids. Each year approximately 400,000 children from infants to teenagers are diagnosed with ...
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April 1, 2021
Expanding the Horizon of Antibody-Drug Conjugates for Cancer Treatment
This post explores the fast-expanding topic of antibody-drug conjugates (ADCs), including those that have been approved ...
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March 1, 2021
Profiling of Tumor-Infiltrating Immune Cells in Syngeneic Tumor Models to Support Drug Development
Tumor-Infiltrating Immune Cells: Explore how the identification and quantification of tumor-infiltrating lymphocytes ...
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December 18, 2020
Factors to Consider When Selecting a Next Generation Sequencing (NGS) Technology
Explore the main factors you need to consider before choosing and using next generation sequencing (NGS).
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December 16, 2020
Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies
Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role of the microbiota in health and disease, including cancer.
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December 3, 2020
The Latest Developments on PARP Inhibitors for Prostate Cancer Treatment
Review the status of PARP inhibitors (PARPi) for prostate cancer treatment, with a focus on recent developments in drug ...
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November 30, 2020
The Rising Importance of GITR Agonists as Alternative I/O Candidates for Combination Drug Strategies
Explore why glucocorticoid-induced TNFR-related protein (GITR or CD357) agonists are becoming increasingly important as ...
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November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for ...
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November 6, 2020
In Vivo Imaging of Syngeneic Models for Immuno-Oncology Studies
Explore how different imaging modalities are used to monitor in vivo immuno-oncology (I/O) studies in syngeneic tumor ...
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