Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

August 12, 2020 How to Select the Right In Vivo PDX Using PDX-Derived Organoids (PDXO) Select the right in vivo PDX: Explore how 3D in vitro tumor organoids are used to guide in vivo PDX model selection. LEARN MORE
July 30, 2020 Obeticholic Acid: Past, Present, and Future? Review the history of obeticholic acid (OCA) from discovery and proof-of-concept, through clinical trials and approval ... LEARN MORE
July 23, 2020 Digital Pathology Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology. LEARN MORE
July 16, 2020 Next Generation Sequencing 101 A look at the range of next-generation sequencing technologies available today including whole genome, RNA, and whole ... LEARN MORE
July 10, 2020 Immunogenomics in Oncology Drug Development Explore the emerging field of immunogenomics and how it’s being used to answer key questions related to immunotherapy ... LEARN MORE
June 11, 2020 DNA Damage Response (DDR) Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer ... LEARN MORE
June 8, 2020 Using Tumor Organoids to Identify Cancer Biomarkers Review why and how to use 3D in vitro tumor organoids to identify cancer biomarkers. LEARN MORE
May 15, 2020 Top 3 Ways to Use Tumor Organoids for Drug Screening Explore the top 3 ways to use tumor organoids for drug screening: library screening, efficacy quantification screening, ... LEARN MORE
May 7, 2020 Top 4 Applications for Tumor Organoids in Oncology Drug Development Explore the main applications for tumor organoids in preclinical cancer drug development, driven by the unique features ... LEARN MORE
May 5, 2020 HUB Organoids as Human Cancer Models Explore the phenotypic and genetic concordance between HUB patient-derived tumor organoids and the primary human ... LEARN MORE
April 30, 2020 How to Use Tumor Organoids for Immuno-Oncology Applications Explore how to use tumor organoids for immuno-oncology applications, including immunotherapy assessment through co-cultures with autologous and non-autologous immune cells. LEARN MORE
April 28, 2020 PARP Inhibitors: Where Are We in 2020 and What’s Coming Next? Review the current approval status of PARP inhibitors, and what could be coming next for this class of agent, including ... LEARN MORE
April 24, 2020 Modeling Oncogenic RAS and BRAF Mutations Using Colorectal Cancer Organoids Explore how genetically engineered patient-derived tumor organoids are helping to model colorectal cancer and specific ... LEARN MORE
April 22, 2020 The Role of Proteomics in Oncology Biomarker Discovery Explore the evolving role of proteomics in oncology biomarker discovery, specifically identifying and analyzing ... LEARN MORE
April 1, 2020 The Role of Patient-Derived Tumor Organoids in Precision Medicine Explore how patient-derived tumor organoids are used in the clinic to develop novel precision medicine approaches for ... LEARN MORE