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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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April 1, 2020 The Role of Patient-Derived Tumor Organoids in Precision Medicine Explore how patient-derived tumor organoids are used in the clinic to develop novel precision medicine approaches for guiding and informing treatment options. LEARN MORE
March 16, 2020 Tumor Organoid Q&A: PDXO Models and Immuno-Oncology Applications Review the key questions and answers on PDX-derived organoids (PDXO) and tumor organoid immuno-oncology applications ... LEARN MORE
March 12, 2020 Top 10 Questions: HUB Organoid Technology and Models Dr Rajendra Kumari answers the key questions around HUB Organoid technology and tumor organoid models from our recent ... LEARN MORE
March 11, 2020 Top 10 Questions: Liver-Targeted Mitochondrial Uncoupling in NHP Models Dr. Leigh Goedeke, Postdoctoral Fellow at Yale School of Medicine answers the most popular questions from her recent ... LEARN MORE
March 6, 2020 How to Develop Predictive Cancer Biomarkers How to develop predictive cancer biomarkers: Explore the different types and classes of cancer biomarker, and the key ... LEARN MORE
March 5, 2020 Comparison Guide: Carbon Tetrachloride Induction and Choline Deficient Diet Models Compare the key features of popular commercial mouse models for accelerated NAFLD and NASH including fibrosis, such as ... LEARN MORE
February 27, 2020 The Benefits of PDX Models in Head and Neck Cancer Research Explore why patient-derived xenografts (PDX) are an important model in head and neck cancer research, particularly for studying radiation response and deriving next generation organoids. LEARN MORE
February 25, 2020 Using Organoids to Understand Colorectal Cancer Mechanisms and Development Learn how healthy tissue and tumor-derived organoids are used to uncover disease mechanisms, here shining a light on ... LEARN MORE
February 20, 2020 Identify Predictive Biomarkers Using Translational Preclinical Models Explore a variety of methods to identify predictive biomarkers using a range of translational preclinical models ... LEARN MORE
February 18, 2020 Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the ... LEARN MORE
February 13, 2020 Targeting KRAS: Finally Drugging the Undruggable? Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent achievements, and potential future approaches to drugging the once “undruggable” KRAS target. LEARN MORE
February 11, 2020 huPBMC Humanized Mouse Models: De-Risking Graft versus Tumor (GvT) Effects Through a Co-Culture Donor Selection Assay Explore how to use a donor selection assay to limit the chances of graft vs tumor (GvT) effects when using huPBMC ... LEARN MORE
February 7, 2020 Preclinical Biomarker Discovery: Top 17 Questions Review key questions on preclinical biomarker discovery from our recent webinar, answered by Mike Batey. LEARN MORE
February 6, 2020 How to Use Mouse Clinical Trials to Reinterpret Clinical Results Explore how to use mouse clinical trials and analysis by linear mixed models approaches to reinterpret clinical trial ... LEARN MORE
February 4, 2020 How to Quantify Drug Efficacy and Effects in Mouse Clinical Trials Learn how to correctly quantify drug efficacy and effects in mouse clinical trials using a linear mixed models ... LEARN MORE