November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for KRAS-mutated cancers.
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November 6, 2020
In Vivo Imaging of Syngeneic Models for Immuno-Oncology Studies
Explore how different imaging modalities are used to monitor in vivo immuno-oncology (I/O) studies in syngeneic tumor ...
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October 28, 2020
Thermoneutrality and Preclinical Obesity Models
Explore how to improve translatability of preclinical obesity research by using murine thermoneutral conditions.
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October 26, 2020
Applications and Benefits of Engineered Syngeneic Cell Lines
Explore the use and main benefits of engineered syngeneic cell lines for investigating drug targets and biological ...
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October 21, 2020
Meet the CrownBio Team: Dr Marrit Putker, Organoid Research Scientist
Meet the newest member of CrownBio’s organoid team, Marrit Putker, heading up research at our new Utrecht site.
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October 14, 2020
Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models
Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ...
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October 2, 2020
Next Generation Syngeneic Models: Top 14 Questions
Dr Davy Ouyang, CrownBio Vice President of Scientific Research & Innovation answers the most popular questions from his recent syngeneic model webinar, covering the latest research, model developments, and platforms for moving past syngeneics for advanced immuno-oncology studies.
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September 22, 2020
T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates
Review the latest advances in the recall antigen assay, to provide an optimized system for screening and characterizing ...
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September 17, 2020
HUB Technology: The Only Tumor Organoid Platform Available for Oncology Drug Discovery
Explore why adult stem cell (ASC)-derived HUB technology provides the only tumor organoid platform available for ...
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September 15, 2020
Targeting Peroxisome Proliferator-Activated Receptors for NASH Therapy
Review the roles of peroxisome proliferator-activated receptor (PPAR) isotypes in managing hepatic and systemic lipid ...
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September 10, 2020
Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When?
Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based NanoString.
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September 8, 2020
Targeting the Fibroblast Growth Factor Axis for NASH Therapy
Review the roles of members of the FGF19 subclass of fibroblast growth factor (FGF) hormones in NAFLD and NASH, and the ...
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September 3, 2020
Predicting Clinical Treatment Responses Using HUB Tumor Organoids
Explore the power of HUB tumor organoids in predicting clinical response.
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August 27, 2020
Tumor Organoid Applications in Cancer Research
Explore tumor organoid applications in cancer research including metastasis modeling, drug screening, understanding ...
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August 20, 2020
Why Choose Tumor Organoids vs Other 3D In Vitro Models for Oncology Drug Development
Review the key differences between tumor organoids and other 3D in vitro tumor cell cultures, including spheroids, ...
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