January 23, 2020
NASH Clinical Update: What to Expect in 2020
Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 news and who could win the first drug approval for NASH in 2020.
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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January 17, 2020
The Link Between Diabetes and Kidney Disease
Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively ...
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January 16, 2020
How Are Organoids Different from 3D Primary Cell Cultures?
Explore the key differences between organoids and primary cells grown in 3D, from both healthy tissue and tumors.
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January 9, 2020
How to Use Tumor Organoids for Oncology Drug Screening
Review how, and why, to use tumor organoids in in vitro oncology drug screening programs.
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December 3, 2019
Top 12 Questions: Applications of PDXO
Review the top 12 questions on PDX-derived organoid (PDXO) utilities from our recent webinar, answered by Dr. Rajendra ...
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November 29, 2019
Patient Tumors, PDX, and PDXO: Model Correlation Q&A
At our recent webinar we discussed our innovative PDX-derived organoid (PDXO) in vitro platform. We received many interesting questions on how these models correlate with their parental PDX and originating tumors, which we've summarized and had answered here by Dr. Rajendra Kumari, Global Head of Scientific Communication.
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November 26, 2019
Ask the Expert: Successfully Developing PDX-Derived Organoid (PDXO) Models
Review the key questions on the development of PDX-derived organoids (PDXO) from our recent webinar, answered by Dr. ...
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November 22, 2019
The Importance of Companion Diagnostics
Explore the importance of companion diagnostics (CDx) and the benefits of their early adoption and drug codevelopment.
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November 5, 2019
Cancer Biomarkers: Improving Detection and Treatment
Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and ...
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October 30, 2019
The Biological Equivalence of PDXs and PDXOs
Learn about patient-derived xenograft (PDX) and PDX-derived organoid (PDXO) biological equivalence, based on shared genomic diversity, tumor heterogeneity, histopathology, and drug response profiles. Explore how these similarities make the models highly complementary and interchangeable, providing researchers with a patient-relevant in vitro PDXO system and ...
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October 29, 2019
Advances in In Vivo Oncology Models at AACR-NCI-EORTC 2019
In Boston this week we’re presenting all the latest updates across our panels of in vivo oncology models. Catch up with ...
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October 28, 2019
New Organoid Platforms for Oncology and I/O Drug Discovery at AACR-NCI-EORTC 2019
2019 has been an exciting year at CrownBio with the addition of organoid platforms to our portfolio of models and ...
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October 28, 2019
Biomarker Discovery and MOA Evaluation through Genomic and Proteomic Profiling at AACR-NCI-EORTC 2019
This week in Boston we’re presenting data on our new analysis platform and preclinical technologies. This post recaps ...
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October 25, 2019
How to Detect, Characterize, and Evaluate CAR-Ts: Top 13 Questions
Review key questions on preclinical models and rare cell analysis technology for assessing CAR-T cell therapies from ...
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