August 8, 2019
The Development of HUB Organoids
Review the development and use of HUB Organoids, from the first discovery of Lgr5 as an adult stem cell biomarker in the Clevers lab, to the model features and data which have led to their widespread use today.
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July 30, 2019
The Link Between Diabetes and Cardiovascular Disease
Patients with diabetes mellitus (DM) have increased risk of developing cardiovascular disease (CVD) and hypertension. ...
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July 26, 2019
Targeting the CD47/SIRPɑ Axis in Cancer Immunotherapy
Explore why the CD47/SIRPα axis is an important immuno-oncology target and the methods being used to block this axis.
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July 19, 2019
Recapitulating Clinical Metastatic Events in Preclinical Mouse Models
Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process.
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July 18, 2019
Tumor Organoids and the HUB Protocol Method
Review organoid culture techniques and applications, with a focus on tumor organoids developed via HUB protocols.
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July 9, 2019
CAR-T Cell Therapy for Pancreatic Cancer
Explore how CAR-T cell therapy is showing promise as a novel treatment strategy for pancreatic cancer.
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June 20, 2019
Modelling the Full Progression of Type 2 Diabetes | Q&A
Learn how we model the full progression of Type 2 diabetes with improved clinical relevance in this Q&A session with Dr. Yixin “Jim” Wang, Senior VP of Cardiovascular and Metabolic Disease Research at CrownBio.
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June 13, 2019
Comparing Traditional Rodent Models for Metabolic Research
Explore the main features, advantages, and limitations of common rodent models used in preclinical metabolic disease ...
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June 11, 2019
Orthotopic or Subcutaneous Tumor Homograft Models?
When should you use either subcutaneous or orthotopic pancreatic cancer tumor homografts, and where do they best ...
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June 6, 2019
Challenges in Preclinical NASH Modeling
Review the current challenges in preclinical NASH drug development in the run-up to International NASH Day.
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June 4, 2019
The Link Between Obesity and Type 2 Diabetes
Explore the connections between obesity and type 2 diabetes, and how understanding these links can help improve diabetes research and drug development.
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May 30, 2019
Key Differences between hPBMC and hCD34 Humanized Mouse Models
Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the ...
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May 8, 2019
NASH Induction with CCl4
Learn more about NASH induction through CCl4 administration, and the advantages of inducing NASH in a dysmetabolic ...
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May 7, 2019
Combination Therapies and Tumor Homograft Models
Learn more about using tumor homograft models to assess oncology combination regimens, including immunotherapies.
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April 25, 2019
Large-Scale Immunotherapy Screening: How and Why?
Learn more about the need for large-scale cancer immunotherapy screens and the different immunocompetent models ...
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