September 13, 2018
CAR-T Cell Therapy for Solid Tumors
CAR-T cell therapies are currently only approved for blood cancers, but new preclinical research shows promise in using CAR-T cells against solid tumors in gastric cancer.
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September 11, 2018
Using Plasma Ceramides to Predict Coronary Artery Disease
Cardiovascular disease (CVD) is the number one cause of death globally, making improved prognostic disease indicators ...
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September 4, 2018
Prostate Cancer Patient-Derived Xenograft (PDX) Models
Clinically-relevant prostate cancer patient-derived xenograft (PDX) models are notoriously hard to generate. Here we ...
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August 31, 2018
Why Are Prostate Cancer Preclinical Models Hard to Develop?
Prostate cancer is a particularly difficult cancer type to model for preclinical research. Why are prostate cancer ...
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August 17, 2018
Facilitating Drug Discovery with 3D In Vitro Oncology Models
Around 95% of new anticancer drugs eventually fail in clinical trials, despite promising results when tested on 2D in ...
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August 7, 2018
Preclinical Research Models of NAFLD/NASH
Most preclinical models of NAFLD/NASH are limited to studying specific aspects of the disease. In this blog post, you ...
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August 2, 2018
Are Noninvasive Tests Enough for NAFLD/NASH Diagnosis?
There is significant interest in validating strategies for the noninvasive evaluation of fibrosis in NAFLD/NASH. This blog post evaluates the available techniques, including noninvasive echography, and the NHP models available for assessing these new methods.
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July 31, 2018
From Pathogenesis to Treatment with NAFLD/NASH
Non-alcoholic steatohepatitis (NASH) is a hot topic in 2018, with a race to the first approved treatment well under way ...
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July 26, 2018
IDO to I DON’T – IDO1 Inhibitor Development News
As targeted immuno-oncology agents make impressive strides in cancer treatment, researchers are looking for agents that ...
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July 24, 2018
Improving Cardiac Function with FTY720 – ADA 2018
Our ADA presentations this year included a collaborative poster with Pegasus Bio. The studies used our unique panel of ...
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July 19, 2018
Connecting Inflammation, Diabetes, and Obesity
We presented data on our next generation type 2 diabetes (T2D) and obesity rodent models at the ADA Scientific Sessions this year. This included the latest research using the FATZO mouse investigating whether murine models can be used to understand underlying inflammatory mechanisms as they relate to T2D and obesity.
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July 17, 2018
Cardiomyopathy Treatment in Rodent Models – ADA 2018
At ADA 2018, we shared the latest data on our next generation type 2 diabetes (T2D) and obesity rodent models. This ...
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July 5, 2018
Personalized Cancer Immunotherapy
Precision medicine and immunotherapy are currently two of the hottest areas of cancer research. How can immuno-oncology ...
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July 3, 2018
Custom Murine Tumor Homografts for Efficacy Assessment
Murine tumor homografts provide an immunotherapeutic efficacy testing platform with the strengths of GEMM paired with ...
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June 28, 2018
Assessing Combination Therapies in Syngeneic Tumor Models
Combination immunotherapy could enhance the clinical benefits of monotherapies and overcome patient lack of response to ...
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