April 1, 2021
Expanding the Horizon of Antibody-Drug Conjugates for Cancer Treatment
This post explores the fast-expanding topic of antibody-drug conjugates (ADCs), including those that have been approved to date and recent and future innovations that may come to bear on ADCs.
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March 1, 2021
Profiling of Tumor-Infiltrating Immune Cells in Syngeneic Tumor Models to Support Drug Development
Tumor-Infiltrating Immune Cells: Explore how the identification and quantification of tumor-infiltrating lymphocytes ...
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December 18, 2020
Factors to Consider When Selecting a Next Generation Sequencing (NGS) Technology
Explore the main factors you need to consider before choosing and using next generation sequencing (NGS).
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December 16, 2020
Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies
Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role ...
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December 3, 2020
The Latest Developments on PARP Inhibitors for Prostate Cancer Treatment
Review the status of PARP inhibitors (PARPi) for prostate cancer treatment, with a focus on recent developments in drug ...
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November 30, 2020
The Rising Importance of GITR Agonists as Alternative I/O Candidates for Combination Drug Strategies
Explore why glucocorticoid-induced TNFR-related protein (GITR or CD357) agonists are becoming increasingly important as ...
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November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for KRAS-mutated cancers.
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November 6, 2020
In Vivo Imaging of Syngeneic Models for Immuno-Oncology Studies
Explore how different imaging modalities are used to monitor in vivo immuno-oncology (I/O) studies in syngeneic tumor ...
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October 26, 2020
Applications and Benefits of Engineered Syngeneic Cell Lines
Explore the use and main benefits of engineered syngeneic cell lines for investigating drug targets and biological ...
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October 21, 2020
Meet the CrownBio Team: Dr Marrit Putker, Organoid Research Scientist
Meet the newest member of CrownBio’s organoid team, Marrit Putker, heading up research at our new Utrecht site.
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October 14, 2020
Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models
Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy mechanisms of action and response.
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October 2, 2020
Next Generation Syngeneic Models: Top 14 Questions
Dr Davy Ouyang, CrownBio Vice President of Scientific Research & Innovation answers the most popular questions from his ...
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September 22, 2020
T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates
Review the latest advances in the recall antigen assay, to provide an optimized system for screening and characterizing ...
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September 17, 2020
HUB Technology: The Only Tumor Organoid Platform Available for Oncology Drug Discovery
Explore why adult stem cell (ASC)-derived HUB technology provides the only tumor organoid platform available for ...
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September 10, 2020
Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When?
Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ...
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