February 18, 2020
Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease
Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the potential for future clinical use.
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February 13, 2020
Targeting KRAS: Finally Drugging the Undruggable?
Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent ...
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February 11, 2020
huPBMC Humanized Mouse Models: De-Risking Graft versus Tumor (GvT) Effects Through a Co-Culture Donor Selection Assay
Explore how to use a donor selection assay to limit the chances of graft vs tumor (GvT) effects when using huPBMC ...
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February 7, 2020
Preclinical Biomarker Discovery: Top 17 Questions
Review key questions on preclinical biomarker discovery from our recent webinar, answered by Mike Batey.
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February 6, 2020
How to Use Mouse Clinical Trials to Reinterpret Clinical Results
Explore how to use mouse clinical trials and analysis by linear mixed models approaches to reinterpret clinical trial ...
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February 4, 2020
How to Quantify Drug Efficacy and Effects in Mouse Clinical Trials
Learn how to correctly quantify drug efficacy and effects in mouse clinical trials using a linear mixed models ...
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January 31, 2020
How to Optimize Mouse Clinical Trial Study Design
Learn how to optimize mouse clinical trial study design, including choosing how many PDX to use, via a linear mixed models approach.
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January 29, 2020
Mouse Clinical Trial Analysis
Explore the current methods of mouse clinical trial analysis, and how these are improved by using a linear mixed models ...
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January 23, 2020
NASH Clinical Update: What to Expect in 2020
Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 ...
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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January 17, 2020
The Link Between Diabetes and Kidney Disease
Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively impacts renal health, and how diabetic kidney disease can be modeled preclinically.
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January 16, 2020
How Are Organoids Different from 3D Primary Cell Cultures?
Explore the key differences between organoids and primary cells grown in 3D, from both healthy tissue and tumors.
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January 9, 2020
How to Use Tumor Organoids for Oncology Drug Screening
Review how, and why, to use tumor organoids in in vitro oncology drug screening programs.
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December 3, 2019
Top 12 Questions: Applications of PDXO
Review the top 12 questions on PDX-derived organoid (PDXO) utilities from our recent webinar, answered by Dr. Rajendra ...
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November 29, 2019
Patient Tumors, PDX, and PDXO: Model Correlation Q&A
At our recent webinar we discussed our innovative PDX-derived organoid (PDXO) in vitro platform. We received many ...
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