July 5, 2021
Preclinical Models for Bispecific T Cell Engager Development
Last month we hosted a webinar with Dr. Ludovic Bourré, Senior Director of Scientific Engagement at CrownBio, focused on the next generation of preclinical models advancing bispecific T cell engager (BiTE) development.
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June 1, 2021
Ask the Expert: Organoid and Immune Cell Co-Cultures
Dr Yujun Huang, Senior Director Immuno-Oncology at CrownBio, answers the most popular questions from his recent ...
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May 4, 2021
For the Children: Advancing the Cause of Pediatric Cancer Research
Why are cancer treatments for children lagging behind the latest advancements in clinical oncology? CrownBio Director ...
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April 1, 2021
Expanding the Horizon of Antibody-Drug Conjugates for Cancer Treatment
This post explores the fast-expanding topic of antibody-drug conjugates (ADCs), including those that have been approved ...
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March 1, 2021
Profiling of Tumor-Infiltrating Immune Cells in Syngeneic Tumor Models to Support Drug Development
Tumor-Infiltrating Immune Cells: Explore how the identification and quantification of tumor-infiltrating lymphocytes ...
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December 18, 2020
Factors to Consider When Selecting a Next Generation Sequencing (NGS) Technology
Explore the main factors you need to consider before choosing and using next generation sequencing (NGS).
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December 16, 2020
Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies
Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role of the microbiota in health and disease, including cancer.
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December 3, 2020
The Latest Developments on PARP Inhibitors for Prostate Cancer Treatment
Review the status of PARP inhibitors (PARPi) for prostate cancer treatment, with a focus on recent developments in drug ...
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November 30, 2020
The Rising Importance of GITR Agonists as Alternative I/O Candidates for Combination Drug Strategies
Explore why glucocorticoid-induced TNFR-related protein (GITR or CD357) agonists are becoming increasingly important as ...
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November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for ...
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November 6, 2020
In Vivo Imaging of Syngeneic Models for Immuno-Oncology Studies
Explore how different imaging modalities are used to monitor in vivo immuno-oncology (I/O) studies in syngeneic tumor models.
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October 26, 2020
Applications and Benefits of Engineered Syngeneic Cell Lines
Explore the use and main benefits of engineered syngeneic cell lines for investigating drug targets and biological ...
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October 21, 2020
Meet the CrownBio Team: Dr Marrit Putker, Organoid Research Scientist
Meet the newest member of CrownBio’s organoid team, Marrit Putker, heading up research at our new Utrecht site.
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October 14, 2020
Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models
Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ...
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October 2, 2020
Next Generation Syngeneic Models: Top 14 Questions
Dr Davy Ouyang, CrownBio Vice President of Scientific Research & Innovation answers the most popular questions from his ...
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