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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

February 12, 2019 Targeting the FGF/FGFR Signaling Axis with PDX Models Discover the complex range of FGFR family aberrations in cancer and how PDX models are a powerful tool for assessing new FGFR-targeted therapeutic options. LEARN MORE
February 7, 2019 CD40: Targeting Co-Stimulatory Pathways for Cancer Immunotherapy Explore the role of CD40 in cancer immunotherapy, including its background, functions, and why combination regimens may ... LEARN MORE
February 6, 2019 Target Engagement Studies with Syngeneic Tumor Models Syngeneic tumor models are a rapid and high-throughput option for novel drug discovery. Here’s how to use them for ... LEARN MORE
February 5, 2019 Beginners Guide to PBMC Humanized Tumor Models Discover PBMC-humanized tumor models for short-term immunotherapy assessment studies. LEARN MORE
January 31, 2019 How to Test Human-Specific Combination Immunotherapies In Vivo Learn how to evaluate combinations of human-specific checkpoint inhibitors in vivo, with double knock-in humanized drug ... LEARN MORE
January 29, 2019 Using Syngeneic Tumor Models for POC Studies Syngeneic tumor models are a predictive, high-throughput option for validating novel therapeutic approaches. Here’s how ... LEARN MORE
January 24, 2019 Imaging Orthotopic Disease Explore how preclinical imaging helps visualize disease grown at depth in an in vivo, orthotopic setting. LEARN MORE
January 22, 2019 Tumor Heterogeneity in Preclinical Oncology Models Real tumors are complex and heterogeneous, which has long frustrated efforts to recapitulate the disease in a ... LEARN MORE
January 17, 2019 New Biomarkers to Detect Atrial Fibrillation Review the new data identifying brain natriuretic peptide and FGF-23 as biomarkers for detecting atrial fibrillation in ... LEARN MORE
January 15, 2019 Preclinical Imaging of Non-Solid Tumors Learn how preclinical imaging helps overcome the particular challenges associated with modeling leukemia and other ... LEARN MORE
January 10, 2019 Is Exercise the Key to a Healthy Life? Find out why exercise should be a key part of your healthy lifestyle in 2019. LEARN MORE
January 8, 2019 RAS: Targeting the Impossible Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical ... LEARN MORE
January 4, 2019 Selecting Preclinical Models of Diabetes Review the main features you need to consider when selecting preclinical models for type 2 diabetes (T2D) research, ... LEARN MORE
January 2, 2019 Stress Keeping You Up at Night? Blame Your HPA Axis New research into our master “circadian clock” explains why your body responds differently to stress at different times ... LEARN MORE
December 27, 2018 Biomarkers for Dementia and Alzheimer’s Disease Over 47 million people worldwide are living with dementia, the great majority of them due to Alzheimer’s disease (AD). ... LEARN MORE