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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

July 30, 2019 The Link Between Diabetes and Cardiovascular Disease Patients with diabetes mellitus (DM) have increased risk of developing cardiovascular disease (CVD) and hypertension. CVD complications are leading causes of death among the diabetic population. This blog post explores the causal connections between the diabetic condition, macrovascular complications, and hypertension. LEARN MORE
July 26, 2019 Targeting the CD47/SIRPɑ Axis in Cancer Immunotherapy Explore why the CD47/SIRPα axis is an important immuno-oncology target and the methods being used to block this axis. LEARN MORE
July 19, 2019 Recapitulating Clinical Metastatic Events in Preclinical Mouse Models Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process. LEARN MORE
July 18, 2019 Tumor Organoids and the HUB Protocol Method Review organoid culture techniques and applications, with a focus on tumor organoids developed via HUB protocols. LEARN MORE
July 9, 2019 CAR-T Cell Therapy for Pancreatic Cancer Explore how CAR-T cell therapy is showing promise as a novel treatment strategy for pancreatic cancer. LEARN MORE
June 20, 2019 Modelling the Full Progression of Type 2 Diabetes | Q&A Learn how we model the full progression of Type 2 diabetes with improved clinical relevance in this Q&A session with ... LEARN MORE
June 13, 2019 Comparing Traditional Rodent Models for Metabolic Research Explore the main features, advantages, and limitations of common rodent models used in preclinical metabolic disease research. LEARN MORE
June 11, 2019 Orthotopic or Subcutaneous Tumor Homograft Models? When should you use either subcutaneous or orthotopic pancreatic cancer tumor homografts, and where do they best ... LEARN MORE
June 6, 2019 Challenges in Preclinical NASH Modeling Review the current challenges in preclinical NASH drug development in the run-up to International NASH Day. LEARN MORE
June 4, 2019 The Link Between Obesity and Type 2 Diabetes Explore the connections between obesity and type 2 diabetes, and how understanding these links can help improve ... LEARN MORE
May 30, 2019 Key Differences between hPBMC and hCD34 Humanized Mouse Models Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the right model for your studies. LEARN MORE
May 8, 2019 NASH Induction with CCl4 Learn more about NASH induction through CCl4 administration, and the advantages of inducing NASH in a dysmetabolic ... LEARN MORE
May 7, 2019 Combination Therapies and Tumor Homograft Models Learn more about using tumor homograft models to assess oncology combination regimens, including immunotherapies. LEARN MORE
April 25, 2019 Large-Scale Immunotherapy Screening: How and Why? Learn more about the need for large-scale cancer immunotherapy screens and the different immunocompetent models ... LEARN MORE
April 16, 2019 5 Criteria for Choosing a Contract Research Organization Contract research organizations (CROs) vary in capability, quality, experience, cost, and ease of collaboration. Weigh ... LEARN MORE