Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

September 22, 2020 T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates Review the latest advances in the recall antigen assay, to provide an optimized system for screening and characterizing immunomodulatory drug candidates, including recapitulating aspects of a suppressed tumor microenvironment (TME). LEARN MORE
September 17, 2020 HUB Technology: The Only Tumor Organoid Platform Available for Oncology Drug Discovery Explore why adult stem cell (ASC)-derived HUB technology provides the only tumor organoid platform available for ... LEARN MORE
September 10, 2020 Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When? Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ... LEARN MORE
September 3, 2020 Predicting Clinical Treatment Responses Using HUB Tumor Organoids Explore the power of HUB tumor organoids in predicting clinical response. LEARN MORE
August 27, 2020 Tumor Organoid Applications in Cancer Research Explore tumor organoid applications in cancer research including metastasis modeling, drug screening, understanding ... LEARN MORE
August 20, 2020 Why Choose Tumor Organoids vs Other 3D In Vitro Models for Oncology Drug Development Review the key differences between tumor organoids and other 3D in vitro tumor cell cultures, including spheroids, ... LEARN MORE
August 12, 2020 How to Select the Right In Vivo PDX Using PDX-Derived Organoids (PDXO) Select the right in vivo PDX: Explore how 3D in vitro tumor organoids are used to guide in vivo PDX model selection. LEARN MORE
July 23, 2020 Digital Pathology Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology. LEARN MORE
July 16, 2020 Next Generation Sequencing 101 A look at the range of next-generation sequencing technologies available today including whole genome, RNA, and whole ... LEARN MORE
July 10, 2020 Immunogenomics in Oncology Drug Development Explore the emerging field of immunogenomics and how it’s being used to answer key questions related to immunotherapy ... LEARN MORE
June 11, 2020 DNA Damage Response (DDR) Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer therapeutic strategies. LEARN MORE
June 8, 2020 Using Tumor Organoids to Identify Cancer Biomarkers Review why and how to use 3D in vitro tumor organoids to identify cancer biomarkers. LEARN MORE
May 15, 2020 Top 3 Ways to Use Tumor Organoids for Drug Screening Explore the top 3 ways to use tumor organoids for drug screening: library screening, efficacy quantification screening, ... LEARN MORE
May 7, 2020 Top 4 Applications for Tumor Organoids in Oncology Drug Development Explore the main applications for tumor organoids in preclinical cancer drug development, driven by the unique features ... LEARN MORE
May 5, 2020 HUB Organoids as Human Cancer Models Explore the phenotypic and genetic concordance between HUB patient-derived tumor organoids and the primary human ... LEARN MORE