Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

January 5, 2018 2018 Technology Advances – Applying Next Generation Sequencing to Single Cell Analysis It is an axiom in biology that expression of genotype determines phenotype. This means, for the large part, that the reason a cell does specialized functions is due to its mRNA and subsequent protein expression profile. LEARN MORE
December 19, 2017 2017 Review: Precision Medicine - From Traditional to Tailored Treatment With continued advances in technology, and the increasing focus on individualized therapy, the field of precision ... LEARN MORE
December 14, 2017 2017 Review: The Continued Rise of Immunotherapy We CrownBio blog writers have been tasked with looking back at 2017 and reflecting on this year’s game changers in ... LEARN MORE
December 7, 2017 2017 Review: PARP Inhibitor Update and Approvals As the holiday season approaches, CrownBio is celebrating with a look back over the important research and scientific ... LEARN MORE
December 1, 2017 Mouse Clinical Trials - The Power Behind Study Design: Top 10 Questions Mouse Clinical Trials (MCT) using patient-derived xenograft (PDX) models are a key preclinical tool for predicting drug ... LEARN MORE
November 28, 2017 How Gut Bacteria Influence Cancer Treatment Efficacy Over the past few years, scientists have come to a deeper understanding of how microorganisms can be seen as a major ... LEARN MORE
November 20, 2017 Misidentified Cell Lines: The Scale of the Problem and How to Avoid It Cell lines have been the cornerstone of life science research for decades. Yet they’ve been misidentified and misused almost as long as they’ve been in existence. Some staggering figures exist: the German DSMZ cell repository at one time reported that 18% of its human cell line stocks were cross-contaminated with other cell lines. LEARN MORE
November 10, 2017 EORTC 2017 Short Talk Review Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune ... LEARN MORE
November 8, 2017 Humanized Mouse Clinical Trials for Immunotherapy Development Recent posts have covered the different types of mouse clinical trial (MCT) and which is most suited to any given drug ... LEARN MORE
November 3, 2017 Using PDX as Surrogate Models for TME Investigation The diversity of cancers is due to the fact that there are numerous different types, along with many different ... LEARN MORE
October 31, 2017 How to Choose the Right Type of Mouse Clinical Trial As covered in our recent blog post, Mouse Clinical Trials using patient-derived xenograft (PDX) models provide more predictive outcomes during preclinical studies, hopefully resulting in an improved success rate in clinical trials. LEARN MORE
October 26, 2017 Post FDA Approval: CAR-T Therapy Key Facts A few weeks ago, the FDA issued a historic approval of the first cancer cell therapy using a chimeric antigen receptor ... LEARN MORE
October 24, 2017 Top 5 Reasons To Use Mouse Clinical Trials Preclinical oncology drug development needs new tools and approaches. Current methods result in 95% attrition rates for ... LEARN MORE
October 19, 2017 Quick Guide: Top 3 AML Approval Trends for 2017 Acute myeloid leukemia has been the focus of much drug development, but few drug approvals, for the past few decades. ... LEARN MORE
October 17, 2017 The Role of Gut Microbiota and Implications for IBD Over the past 10 years, scientists have discovered that changes in the composition of the gut microbiota play a pivotal ... LEARN MORE