June 13, 2017Breast Cancer PDX Models
Patient-derived xenograft (PDX) models enhance predictability in oncology preclinical studies. Never established in vitro, PDX closely recapitulate original tumors, including histo- and molecular pathology, driver mutations, and oncogenic changes. This provides highly predictive models, correlating well with patient response to SoC, to inform on clinical ...
May 23, 2017When to Use Conventional Cell Line Derived Xenograft Models
With the creation and increased use of “new” xenograft models (such as patient-derived xenografts, or PDX), we are often asked which is the right model to use for different in vivo studies, and when to use conventional “cell line derived” xenografts vs the patient-derived alternatives.