January 5, 2018
2018 Technology Advances – Applying Next Generation Sequencing to Single Cell Analysis
It is an axiom in biology that expression of genotype determines phenotype. This means, for the large part, that the reason a cell does specialized functions is due to its mRNA and subsequent protein expression profile.
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December 19, 2017
2017 Review: Precision Medicine - From Traditional to Tailored Treatment
With continued advances in technology, and the increasing focus on individualized therapy, the field of precision ...
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December 14, 2017
2017 Review: The Continued Rise of Immunotherapy
We CrownBio blog writers have been tasked with looking back at 2017 and reflecting on this year’s game changers in ...
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December 7, 2017
2017 Review: PARP Inhibitor Update and Approvals
As the holiday season approaches, CrownBio is celebrating with a look back over the important research and scientific ...
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December 1, 2017
Mouse Clinical Trials - The Power Behind Study Design: Top 10 Questions
Mouse Clinical Trials (MCT) using patient-derived xenograft (PDX) models are a key preclinical tool for predicting drug ...
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November 28, 2017
How Gut Bacteria Influence Cancer Treatment Efficacy
Over the past few years, scientists have come to a deeper understanding of how microorganisms can be seen as a major ...
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November 20, 2017
Misidentified Cell Lines: The Scale of the Problem and How to Avoid It
Cell lines have been the cornerstone of life science research for decades. Yet they’ve been misidentified and misused almost as long as they’ve been in existence. Some staggering figures exist: the German DSMZ cell repository at one time reported that 18% of its human cell line stocks were cross-contaminated with other cell lines.
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November 10, 2017
EORTC 2017 Short Talk Review
Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune ...
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November 8, 2017
Humanized Mouse Clinical Trials for Immunotherapy Development
Recent posts have covered the different types of mouse clinical trial (MCT) and which is most suited to any given drug ...
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November 3, 2017
Using PDX as Surrogate Models for TME Investigation
The diversity of cancers is due to the fact that there are numerous different types, along with many different ...
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October 31, 2017
How to Choose the Right Type of Mouse Clinical Trial
As covered in our recent blog post, Mouse Clinical Trials using patient-derived xenograft (PDX) models provide more predictive outcomes during preclinical studies, hopefully resulting in an improved success rate in clinical trials.
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October 26, 2017
Post FDA Approval: CAR-T Therapy Key Facts
A few weeks ago, the FDA issued a historic approval of the first cancer cell therapy using a chimeric antigen receptor ...
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October 24, 2017
Top 5 Reasons To Use Mouse Clinical Trials
Preclinical oncology drug development needs new tools and approaches. Current methods result in 95% attrition rates for ...
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October 19, 2017
Quick Guide: Top 3 AML Approval Trends for 2017
Acute myeloid leukemia has been the focus of much drug development, but few drug approvals, for the past few decades. ...
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October 17, 2017
The Role of Gut Microbiota and Implications for IBD
Over the past 10 years, scientists have discovered that changes in the composition of the gut microbiota play a pivotal ...
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