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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

November 26, 2019 Ask the Expert: Successfully Developing PDX-Derived Organoid (PDXO) Models Review the key questions on the development of PDX-derived organoids (PDXO) from our recent webinar, answered by Dr. Rajendra Kumari, Global Head of Scientific Communication. LEARN MORE
November 22, 2019 The Importance of Companion Diagnostics Explore the importance of companion diagnostics (CDx) and the benefits of their early adoption and drug codevelopment. LEARN MORE
November 5, 2019 Cancer Biomarkers: Improving Detection and Treatment Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and ... LEARN MORE
October 30, 2019 The Biological Equivalence of PDXs and PDXOs Learn about patient-derived xenograft (PDX) and PDX-derived organoid (PDXO) biological equivalence, based on shared ... LEARN MORE
October 29, 2019 Advances in In Vivo Oncology Models at AACR-NCI-EORTC 2019 In Boston this week we’re presenting all the latest updates across our panels of in vivo oncology models. Catch up with ... LEARN MORE
October 28, 2019 New Organoid Platforms for Oncology and I/O Drug Discovery at AACR-NCI-EORTC 2019 2019 has been an exciting year at CrownBio with the addition of organoid platforms to our portfolio of models and ... LEARN MORE
October 28, 2019 Biomarker Discovery and MOA Evaluation through Genomic and Proteomic Profiling at AACR-NCI-EORTC 2019 This week in Boston we’re presenting data on our new analysis platform and preclinical technologies. This post recaps all the new information on genomic and proteomic profiling of PDX models, our automated biomarker discovery platform, and deep proteomics in syngeneic models to uncover anti-PD-1 mechanism of action. LEARN MORE
October 25, 2019 How to Detect, Characterize, and Evaluate CAR-Ts: Top 13 Questions Review key questions on preclinical models and rare cell analysis technology for assessing CAR-T cell therapies from ... LEARN MORE
October 24, 2019 Graft-versus-Host Disease: Types and How to Model Them Review the different types of graft-versus-host disease (GvHD) and the preclinical models (including humanized mice) ... LEARN MORE
October 22, 2019 Dietary Mouse Models of NASH: Comparing the AMLN Diets and the MS-NASH Mouse Compare the key features of commercial dietary mouse models of NASH, including disease induction by the AMLN and GAN ... LEARN MORE
October 4, 2019 What are PDX-Derived Organoids (PDXOs)? Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models. LEARN MORE
September 27, 2019 Preclinical Obesity Study Design: Top 10 Questions Review the top 10 questions on optimizing preclinical obesity studies and model selection from our recent webinar, ... LEARN MORE
September 19, 2019 Key Discoveries in the Development of Modern HUB Organoids Learn about the key research discoveries leading to the development of modern HUB Organoids. LEARN MORE
September 17, 2019 Targeting Tumor-Associated Antigens and Tumor-Specific Antigens Learn more about targeting human tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs) in immunotherapy ... LEARN MORE
September 13, 2019 HUB Tumor Organoids: Top 15 Questions Review the key questions on HUB tumor organoids from our recent webinar, answered by Dr Sylvia Boj, Hubrecht Organoid ... LEARN MORE