Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

November 6, 2020 In Vivo Imaging of Syngeneic Models for Immuno-Oncology Studies Explore how different imaging modalities are used to monitor in vivo immuno-oncology (I/O) studies in syngeneic tumor models. LEARN MORE
October 26, 2020 Applications and Benefits of Engineered Syngeneic Cell Lines Explore the use and main benefits of engineered syngeneic cell lines for investigating drug targets and biological ... LEARN MORE
October 21, 2020 Meet the CrownBio Team: Dr Marrit Putker, Organoid Research Scientist Meet the newest member of CrownBio’s organoid team, Marrit Putker, heading up research at our new Utrecht site. LEARN MORE
October 14, 2020 Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ... LEARN MORE
October 2, 2020 Next Generation Syngeneic Models: Top 14 Questions Dr Davy Ouyang, CrownBio Vice President of Scientific Research & Innovation answers the most popular questions from ... LEARN MORE
September 22, 2020 T Cell Dysfunction Assays for In Vitro Screening of Immunomodulatory Drug Candidates Review the latest advances in the recall antigen assay, to provide an optimized system for screening and characterizing ... LEARN MORE
September 17, 2020 HUB Technology: The Only Tumor Organoid Platform Available for Oncology Drug Discovery Explore why adult stem cell (ASC)-derived HUB technology provides the only tumor organoid platform available for oncology drug discovery. LEARN MORE
September 10, 2020 Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When? Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ... LEARN MORE
September 3, 2020 Predicting Clinical Treatment Responses Using HUB Tumor Organoids Explore the power of HUB tumor organoids in predicting clinical response. LEARN MORE
August 27, 2020 Tumor Organoid Applications in Cancer Research Explore tumor organoid applications in cancer research including metastasis modeling, drug screening, understanding ... LEARN MORE
August 20, 2020 Why Choose Tumor Organoids vs Other 3D In Vitro Models for Oncology Drug Development Review the key differences between tumor organoids and other 3D in vitro tumor cell cultures, including spheroids, which influences model choice for oncology drug development use. LEARN MORE
August 12, 2020 How to Select the Right In Vivo PDX Using PDX-Derived Organoids (PDXO) Select the right in vivo PDX: Explore how 3D in vitro tumor organoids are used to guide in vivo PDX model selection. LEARN MORE
July 23, 2020 Digital Pathology Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology. LEARN MORE
July 16, 2020 Next Generation Sequencing 101 A look at the range of next-generation sequencing technologies available today including whole genome, RNA, and whole ... LEARN MORE
July 10, 2020 Immunogenomics in Oncology Drug Development Explore the emerging field of immunogenomics and how it’s being used to answer key questions related to immunotherapy ... LEARN MORE