September 13, 2016
Obesity Linked To Self-Eating Beige Fat
Humans, like all mammals, have two types of fat with completely opposite functions: white, which stores energy and when present in excess is linked with diabetes and obesity; and brown, which produces heat by burning energy and is associated with leanness. Recently, a third type of fat was discovered within white fat, called beige fat. Beige fat cells can ...
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September 6, 2016
All About Leukemia for Childhood Cancer Month
September is Childhood Cancer Awareness Month, raising awareness and providing time for discussion on this deadly group ...
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August 23, 2016
Put Your Glasses On, Tumor Pharmacology Goes 3D
Attrition rates in oncology drug development are higher than in other disease areas, with almost 95% of compounds ...
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August 2, 2016
Study Finds Perfect Therapeutic Match To Fight a Common Form of Leukemia
Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer, characterized by an excessive ...
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July 22, 2016
Mystery Solved: Chemotherapy and Immunotherapy Partners in Crime to Kill Advanced Cancer
Cancer cells have the ability to evade the immune system by exploiting a self-regulatory mechanism that immune cells ...
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July 15, 2016
Warming up the Issue of Heat Loss
Obesity was classified as a disease by the American Medical Association in 2013, and has become a serious epidemic ...
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July 7, 2016
Cancer Cell Lines: Immortal Champions in Oncology Drug Discovery
Human cancer cell lines are a powerful model system that can be propagated virtually indefinitely in culture, and manipulated to assess sensitivity to anticancer drugs or to investigate the molecular factors behind response to therapy. Oncology research using cancer cell lines has provided meaningful insights into many aspects of cancer susceptibility to ...
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May 19, 2016
Large-Scale Screening Using Patient Avatars Aid Clinical Trial Design
As scientists are learning about the heterogeneity between patients that supposedly have the same tumor, they are ...
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May 10, 2016
Can We Conquer Drug Resistance in Lung Cancer?
At the beginning of the last century lung cancer was a rare disease. However, as early as the end of the 1900s, it had ...
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March 8, 2016
Novo Nordisk Leads the Way to Cardiovascular Safety in Diabetes Treatment
Diabetes is one of the largest global health emergencies of the 21st century. Every year an increasing number of people ...
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January 20, 2016
Avatar Trial Identifies New Treatment Route for Melanoma Patients
Melanoma accounts for approximately five percent of all skin cancer cases, yet it is responsible for nearly 75 percent of skin cancer-related deaths. The BRAF gene is frequently mutated in melanoma, leading to aberrant activation of an important growth pathway. Melanoma patients who receive treatment with targeted therapies that inhibit activated BRAF ...
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December 16, 2015
The Bloody Business Of Tandem Duplications in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is the most common form of aggressive hematologic malignancy affecting adults. AML is ...
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December 8, 2015
Syngeneic Models Take Center Stage In Immunotherapy
Syngeneic models were developed over 50 years ago as early in vivo models for oncology drug development, consisting of ...
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December 1, 2015
Fatty Liver Disease And The Need for New Translational Models
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in developed countries, occurring when fat ...
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November 24, 2015
Epithelial To Mesenchymal Transition: A Step Back For Cancer Cells, A Step Forward For Drug Discovery
Metastasis remains the main cause of cancer-related mortality, despite major scientific advances in the understanding ...
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