Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

June 12, 2018 Leveraging PDX Models for In Vitro and Ex Vivo Assays Patient-derived xenografts (PDX) are the most predictive and translational xenograft models available for preclinical oncology research. However, by their nature, they are restricted to in vivo use and are often too costly and not amenable for platforms such as high throughput drug screening. This blog post looks at the in vitro and ex vivo assays that are ... LEARN MORE
June 7, 2018 Is an Approved NASH Therapy on the Way? Non-alcoholic steatohepatitis (NASH) is an unmet medical need with no approved therapies and debilitating consequences ... LEARN MORE
June 5, 2018 PDX and Personalized Medicine We discussed patient-derived xenografts (PDX) previously, from how to establish the models to when to add them to ... LEARN MORE
May 31, 2018 Predictive Immuno-Oncology Studies with Humanized PDX Patient-derived xenograft (PDX) models are typically immunodeficient and inappropriate for most immuno-oncology (I/O) ... LEARN MORE
May 29, 2018 Webinar FAQ: PDX Models in Drug Discovery Assays Patient-derived xenografts (PDX) are the most predictive and translational preclinical xenograft models available for ... LEARN MORE
May 24, 2018 Webinar FAQ: Humanized PDX Models in Immuno-Oncology Patient-derived xenografts (PDX) support highly translational preclinical oncology research, but were historically ... LEARN MORE
May 22, 2018 Immuno-Oncology and the Microbiome at AACR 2018 CrownBio presented thirteen posters at AACR 2018, sharing our latest internal research into patient derived xenografts, humanized models, murine immuno-oncology models, and in vitro/ex vivo platforms. One particularly interesting poster we presented explored gut microbiota modulation following treatment with a PD-1 inhibitor, with potential implications for ... LEARN MORE
May 17, 2018 Genetically Engineered or Syngeneic Mouse Models? Mouse models are a mainstay of preclinical cancer research, and immunocompetent model use is rising with continued ... LEARN MORE
May 15, 2018 Murine Homograft Tumor Models at AACR 2018 We presented a wide range of immuno-oncology model data at AACR 2018, with three of our thirteen posters covering our ... LEARN MORE
May 10, 2018 In Vitro and Ex Vivo Assay Platforms at AACR 2018 We presented a wide range of oncology modelling capabilities at AACR 2018, spanning the breadth of preclinical ... LEARN MORE
May 8, 2018 Latest Data on PDX Models at AACR 2018 We presented the latest data on our PDX models at this year’s AACR Annual Meeting in Chicago, with new studies on DLBCL models with diverse genotypes for BTK inhibitor testing, comparison of WES and RNAseq in PDX models, and on using PDX as a new model system to investigate the tumor microenvironment (TME). LEARN MORE
May 3, 2018 Humanized Mouse Model Posters at AACR 2018 CrownBio presented thirteen posters at AACR 2018, showcasing a wide range of our oncology and immuno-oncology ... LEARN MORE
April 27, 2018 Understanding Cancer Progression and Metastasis “Cancer progression” is the process by which this disease goes from bad to worse. Molecularly, the course of cancer ... LEARN MORE
April 20, 2018 Preclinical Assessment of Osimertinib for NSCLC with EGFR Exon 20 Insertions NSCLC patients with EGFR exon 20 insertions lack treatment options, partly due to a lack of patient genotype-relevant ... LEARN MORE
April 13, 2018 The Establishment and Characterization of PDX Models Patient-derived xenograft models (PDX) support more predictive, clinically-representative in vivo oncology studies than ... LEARN MORE