February 27, 2020
The Benefits of PDX Models in Head and Neck Cancer Research
Explore why patient-derived xenografts (PDX) are an important model in head and neck cancer research, particularly for studying radiation response and deriving next generation organoids.
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February 25, 2020
Using Organoids to Understand Colorectal Cancer Mechanisms and Development
Learn how healthy tissue and tumor-derived organoids are used to uncover disease mechanisms, here shining a light on ...
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February 20, 2020
Identify Predictive Biomarkers Using Translational Preclinical Models
Explore a variety of methods to identify predictive biomarkers using a range of translational preclinical models ...
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February 18, 2020
Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease
Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the ...
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February 13, 2020
Targeting KRAS: Finally Drugging the Undruggable?
Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent ...
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February 11, 2020
huPBMC Humanized Mouse Models: De-Risking Graft versus Tumor (GvT) Effects Through a Co-Culture Donor Selection Assay
Explore how to use a donor selection assay to limit the chances of graft vs tumor (GvT) effects when using huPBMC ...
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February 7, 2020
Preclinical Biomarker Discovery: Top 17 Questions
Review key questions on preclinical biomarker discovery from our recent webinar, answered by Mike Batey.
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February 6, 2020
How to Use Mouse Clinical Trials to Reinterpret Clinical Results
Explore how to use mouse clinical trials and analysis by linear mixed models approaches to reinterpret clinical trial ...
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February 4, 2020
How to Quantify Drug Efficacy and Effects in Mouse Clinical Trials
Learn how to correctly quantify drug efficacy and effects in mouse clinical trials using a linear mixed models ...
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January 31, 2020
How to Optimize Mouse Clinical Trial Study Design
Learn how to optimize mouse clinical trial study design, including choosing how many PDX to use, via a linear mixed ...
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January 29, 2020
Mouse Clinical Trial Analysis
Explore the current methods of mouse clinical trial analysis, and how these are improved by using a linear mixed models approach.
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January 23, 2020
NASH Clinical Update: What to Expect in 2020
Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 ...
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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January 17, 2020
The Link Between Diabetes and Kidney Disease
Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively ...
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January 16, 2020
How Are Organoids Different from 3D Primary Cell Cultures?
Explore the key differences between organoids and primary cells grown in 3D, from both healthy tissue and tumors.
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