Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Cvmd

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August 7, 2018 Preclinical Research Models of NAFLD/NASH Most preclinical models of NAFLD/NASH are limited to studying specific aspects of the disease. In this blog post, you can review ideal applications for currently available NAFLD/NASH models and discover a new, more translatable choice for preclinical drug development. LEARN MORE
August 2, 2018 Are Noninvasive Tests Enough for NAFLD/NASH Diagnosis? There is significant interest in validating strategies for the noninvasive evaluation of fibrosis in NAFLD/NASH. This ... LEARN MORE
July 31, 2018 From Pathogenesis to Treatment with NAFLD/NASH Non-alcoholic steatohepatitis (NASH) is a hot topic in 2018, with a race to the first approved treatment well under way ... LEARN MORE
July 24, 2018 Improving Cardiac Function with FTY720 – ADA 2018 Our ADA presentations this year included a collaborative poster with Pegasus Bio. The studies used our unique panel of ... LEARN MORE
July 19, 2018 Connecting Inflammation, Diabetes, and Obesity We presented data on our next generation type 2 diabetes (T2D) and obesity rodent models at the ADA Scientific Sessions ... LEARN MORE
July 17, 2018 Cardiomyopathy Treatment in Rodent Models – ADA 2018 At ADA 2018, we shared the latest data on our next generation type 2 diabetes (T2D) and obesity rodent models. This ... LEARN MORE
June 19, 2018 DGAT2 Inhibition Doesn’t Affect Plasma Triglycerides, VLDL ApoB In a new study published in Cell Metabolism, McClaren et al utilize a variety of translational models, including both mouse models and non-human primate (NHP) models of obesity, to explore a potential therapeutic target for dyslipidemia. Their study focused on the effects of DGAT2 inhibition on lipid metabolism and whole-body metabolic flux. LEARN MORE
June 7, 2018 Is an Approved NASH Therapy on the Way? Non-alcoholic steatohepatitis (NASH) is an unmet medical need with no approved therapies and debilitating consequences ... LEARN MORE
March 22, 2018 Are There Are Five Types of Diabetes? New research suggests that there are five types of diabetes, rather than simply Type 1 or Type 2. Understanding ... LEARN MORE
March 7, 2018 New Technique Opens Novel Approaches to Insulin Resistance A newly-described technique could open multiple lines of investigation into the pathophysiology and treatment of ... LEARN MORE
October 10, 2017 ADA 2017 Video Poster Review Naturally Diabetic NHP Immune Cell Changes Correspond to Human Type 2 Diabetes While changes in immune cell distribution have been shown to correlate with disease progression in human type 2 diabetes, similar studies have not been carried out in spontaneously diabetic NHPs, which are highly translatable preclinical models for diabetes and other metabolic ... LEARN MORE
September 28, 2017 Impact of Anesthesia During Comprehensive Assessments On Glucose Homeostasis in Diabetic NHPs In the clinic, either an oral glucose (oGTT) or mixed meal (MMTT) tolerance test is used to provide comprehensive ... LEARN MORE
September 14, 2017 First Type 2 Diabetes Publication Comparing Pros and Cons of Two Preclinical Continuous Glucose Monitoring Systems Significant Correlation between Blood Glucose Levels Measured by Glucometer and both the Dexcom G4 Platinum and HD-XG ... LEARN MORE
August 31, 2017 Recent Type 2 Diabetes Publication Demonstrates Preclinical Study Benefits of Continuous Glucose Monitoring Daily Blood Glucose Fluctuations in Normal and Diabetic NHPs from Wang et al. J Endocrinol Invest 2017;40(9): 967-977. ... LEARN MORE
August 17, 2017 How to Optimize your Non GLP Toxicology Studies Most new drug candidates fail in the clinic because they are not efficacious or are not safe. Optimizing non-clinical ... LEARN MORE