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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Cvmd

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March 11, 2020 Top 10 Questions: Liver-Targeted Mitochondrial Uncoupling in NHP Models Dr. Leigh Goedeke, Postdoctoral Fellow at Yale School of Medicine answers the most popular questions from her recent fatty liver disease webinar, covering liver-targeted mitochondrial uncoupling proof of concept studies in NHP models. LEARN MORE
March 5, 2020 Comparison Guide: Carbon Tetrachloride Induction and Choline Deficient Diet Models Compare the key features of popular commercial mouse models for accelerated NAFLD and NASH including fibrosis, such as ... LEARN MORE
February 18, 2020 Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the ... LEARN MORE
January 23, 2020 NASH Clinical Update: What to Expect in 2020 Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 ... LEARN MORE
January 17, 2020 The Link Between Diabetes and Kidney Disease Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively ... LEARN MORE
October 22, 2019 Dietary Mouse Models of NASH: Comparing the AMLN Diets and the MS-NASH Mouse Compare the key features of commercial dietary mouse models of NASH, including disease induction by the AMLN and GAN ... LEARN MORE
September 27, 2019 Preclinical Obesity Study Design: Top 10 Questions Review the top 10 questions on optimizing preclinical obesity studies and model selection from our recent webinar, answered by Dr Fred Beasley, Director of Scientific Engagement. LEARN MORE
August 27, 2019 Banana Tolerance Test: A New Stress-Free OGTT Method Banana Tolerance Test: A New Stress-Free OGTT Method Learn more about the banana tolerance test, which shares ... LEARN MORE
August 13, 2019 Continuous Glucose Monitoring in NHP Models Discover continuous glucose monitoring as an enhanced technique for preclinical blood glucose measurement in NHP models ... LEARN MORE
July 30, 2019 The Link Between Diabetes and Cardiovascular Disease Patients with diabetes mellitus (DM) have increased risk of developing cardiovascular disease (CVD) and hypertension. ... LEARN MORE
June 20, 2019 Modelling the Full Progression of Type 2 Diabetes | Q&A Learn how we model the full progression of Type 2 diabetes with improved clinical relevance in this Q&A session with Dr. Yixin “Jim” Wang, Senior VP of Cardiovascular and Metabolic Disease Research at CrownBio. LEARN MORE
June 13, 2019 Comparing Traditional Rodent Models for Metabolic Research Explore the main features, advantages, and limitations of common rodent models used in preclinical metabolic disease ... LEARN MORE
June 6, 2019 Challenges in Preclinical NASH Modeling Review the current challenges in preclinical NASH drug development in the run-up to International NASH Day. LEARN MORE
June 4, 2019 The Link Between Obesity and Type 2 Diabetes Explore the connections between obesity and type 2 diabetes, and how understanding these links can help improve ... LEARN MORE
May 8, 2019 NASH Induction with CCl4 Learn more about NASH induction through CCl4 administration, and the advantages of inducing NASH in a dysmetabolic ... LEARN MORE