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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Cvmd

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September 15, 2020 Targeting Peroxisome Proliferator-Activated Receptors for NASH Therapy Review the roles of peroxisome proliferator-activated receptor (PPAR) isotypes in managing hepatic and systemic lipid metabolism, glucose homeostasis, and lipotoxic inflammation. Explore the clinical landscape for therapeutic PPAR agonism toward treating fatty liver diseases including NASH. LEARN MORE
September 8, 2020 Targeting the Fibroblast Growth Factor Axis for NASH Therapy Review the roles of members of the FGF19 subclass of fibroblast growth factor (FGF) hormones in NAFLD and NASH, and the ... LEARN MORE
July 30, 2020 Obeticholic Acid: Past, Present, and Future? Review the history of obeticholic acid (OCA) from discovery and proof-of-concept, through clinical trials and approval ... LEARN MORE
March 11, 2020 Top 10 Questions: Liver-Targeted Mitochondrial Uncoupling in NHP Models Dr. Leigh Goedeke, Postdoctoral Fellow at Yale School of Medicine answers the most popular questions from her recent ... LEARN MORE
March 5, 2020 Comparison Guide: Carbon Tetrachloride Induction and Choline Deficient Diet Models Compare the key features of popular commercial mouse models for accelerated NAFLD and NASH including fibrosis, such as ... LEARN MORE
February 18, 2020 Using Liver-Targeted Mitochondrial Uncoupling to Resolve Fatty Liver Disease Explore how liver-targeted mitochondrial uncoupling is resolving fatty liver disease in preclinical models, with the ... LEARN MORE
January 23, 2020 NASH Clinical Update: What to Expect in 2020 Review the rapidly evolving non-alcoholic steatohepatitis (NASH) clinical landscape, with a roundup of all the big 2019 news and who could win the first drug approval for NASH in 2020. LEARN MORE
January 17, 2020 The Link Between Diabetes and Kidney Disease Learn more about the link between diabetes and kidney disease, including three main ways that hyperglycemia negatively ... LEARN MORE
October 22, 2019 Dietary Mouse Models of NASH: Comparing the AMLN Diets and the MS-NASH Mouse Compare the key features of commercial dietary mouse models of NASH, including disease induction by the AMLN and GAN ... LEARN MORE
September 27, 2019 Preclinical Obesity Study Design: Top 10 Questions Review the top 10 questions on optimizing preclinical obesity studies and model selection from our recent webinar, ... LEARN MORE
August 27, 2019 Banana Tolerance Test: A New Stress-Free OGTT Method Banana Tolerance Test: A New Stress-Free OGTT Method Learn more about the banana tolerance test, which shares beneficial OGTT features while also being stress-free. LEARN MORE
August 13, 2019 Continuous Glucose Monitoring in NHP Models Discover continuous glucose monitoring as an enhanced technique for preclinical blood glucose measurement in NHP models ... LEARN MORE
July 30, 2019 The Link Between Diabetes and Cardiovascular Disease Patients with diabetes mellitus (DM) have increased risk of developing cardiovascular disease (CVD) and hypertension. ... LEARN MORE
June 20, 2019 Modelling the Full Progression of Type 2 Diabetes | Q&A Learn how we model the full progression of Type 2 diabetes with improved clinical relevance in this Q&A session with ... LEARN MORE
June 13, 2019 Comparing Traditional Rodent Models for Metabolic Research Explore the main features, advantages, and limitations of common rodent models used in preclinical metabolic disease ... LEARN MORE