Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Cvmd

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October 10, 2017 ADA 2017 Video Poster Review Naturally Diabetic NHP Immune Cell Changes Correspond to Human Type 2 Diabetes While changes in immune cell distribution have been shown to correlate with disease progression in human type 2 diabetes, similar studies have not been carried out in spontaneously diabetic NHPs, which are highly translatable preclinical models for diabetes and other metabolic ... LEARN MORE
September 28, 2017 Impact of Anesthesia During Comprehensive Assessments On Glucose Homeostasis in Diabetic NHPs In the clinic, either an oral glucose (oGTT) or mixed meal (MMTT) tolerance test is used to provide comprehensive ... LEARN MORE
September 14, 2017 First Type 2 Diabetes Publication Comparing Pros and Cons of Two Preclinical Continuous Glucose Monitoring Systems Significant Correlation between Blood Glucose Levels Measured by Glucometer and both the Dexcom G4 Platinum and HD-XG ... LEARN MORE
August 31, 2017 Recent Type 2 Diabetes Publication Demonstrates Preclinical Study Benefits of Continuous Glucose Monitoring Daily Blood Glucose Fluctuations in Normal and Diabetic NHPs from Wang et al. J Endocrinol Invest 2017;40(9): 967-977. ... LEARN MORE
August 17, 2017 How to Optimize your Non GLP Toxicology Studies Most new drug candidates fail in the clinic because they are not efficacious or are not safe. Optimizing non-clinical ... LEARN MORE
August 1, 2017 NASH Drug Development Race Intensifies There is no FDA-approved treatment for NASH, which affects 3-5% of Americans. Competition to deliver the first ... LEARN MORE
July 27, 2017 Polycystic Kidney Disease (PKD): The Argument for Multiple Rodent Models Rodent models of PKD are critical to studying both its molecular basis and progression, but the complexity of Polycystic kidney disease's cellular alterations and signaling pathways make the leap from preclinical studies to approved treatment of human disease almost impossible. The use of multiple animal models in parallel may be the most effective ... LEARN MORE
July 13, 2017 Progress Towards a Cure for Polycystic Kidney Disease Polycystic kidney disease (polycystic kidney syndrome, PKD, or PCKD) is a genetic disorder in which numerous abdominal ... LEARN MORE
June 15, 2017 Why the Current Excitement over Krill in CVD? Krill are small crustaceans found in all the world's oceans, which have been harvested as a human and animal food ... LEARN MORE
June 6, 2017 PCSK9 Inhibitor Data in Diabetic Patients to be Highlighted at ADA 2017 Recent years have witnessed a change in cholesterol-lowering compounds - from your parents’ standard statin treatment ... LEARN MORE
May 18, 2017 Can We Develop Translational Platforms that Model Multiple Aspects of Human Diabetes? A significant challenge in the development of new anti-diabetic therapies is the lack of translational platforms that can model the pre-diabetic state, diabetes progression, and all the other components of human metabolic syndrome, disease pathophysiology, and associated diabetic comorbidities. Recently a new study(1) from the Tufts Center for the Study of ... LEARN MORE
December 13, 2016 Targeting Cardio-Metabolic Disease Symposium Highlights from the NASH symposium and panel discussion in Boston, MA (Sep 20-21, 2016) Amar Thyagarajan, PhD LEARN MORE
September 27, 2016 All You Need to Know About Non-Alcoholic Fatty Liver Disease Non-Alcoholic Fatty liver disease (NAFLD) is a complex condition where an excessive amount of fat accumulates in the ... LEARN MORE
September 13, 2016 Obesity Linked To Self-Eating Beige Fat Humans, like all mammals, have two types of fat with completely opposite functions: white, which stores energy and when ... LEARN MORE
July 15, 2016 Warming up the Issue of Heat Loss Obesity was classified as a disease by the American Medical Association in 2013, and has become a serious epidemic ... LEARN MORE