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Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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December 16, 2020 Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role of the microbiota in health and disease, including cancer. LEARN MORE
November 10, 2020 SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race? Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for ... LEARN MORE
October 14, 2020 Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ... LEARN MORE
September 10, 2020 Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When? Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ... LEARN MORE
July 23, 2020 Digital Pathology Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology. LEARN MORE
June 11, 2020 DNA Damage Response (DDR) Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer ... LEARN MORE
April 22, 2020 The Role of Proteomics in Oncology Biomarker Discovery Explore the evolving role of proteomics in oncology biomarker discovery, specifically identifying and analyzing biomarkers in cancer drug development. LEARN MORE
March 6, 2020 How to Develop Predictive Cancer Biomarkers How to develop predictive cancer biomarkers: Explore the different types and classes of cancer biomarker, and the key ... LEARN MORE
January 22, 2020 Cancer Cell Line Authentication Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays. LEARN MORE
November 5, 2019 Cancer Biomarkers: Improving Detection and Treatment Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and ... LEARN MORE
September 17, 2019 Targeting Tumor-Associated Antigens and Tumor-Specific Antigens Learn more about targeting human tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs) in immunotherapy development, including therapeutic approaches and preclinical models for assessing TSA/TAA targeting agents. LEARN MORE
August 20, 2019 Circulating Tumor Cells in Preclinical Mouse Models of Metastasis Explore the utility of preclinical mouse models of metastasis to study circulating tumor cells (CTCs) and the ... LEARN MORE
July 19, 2019 Recapitulating Clinical Metastatic Events in Preclinical Mouse Models Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process. LEARN MORE
May 30, 2019 Key Differences between hPBMC and hCD34 Humanized Mouse Models Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the ... LEARN MORE
March 7, 2019 Genetic Abnormality Spectrum in Hematologic Cancers What have we learned about the genetics of hematological cancers, and how can that be modelled for research and drug ... LEARN MORE