December 16, 2020
Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies
Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role of the microbiota in health and disease, including cancer.
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November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for ...
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October 14, 2020
Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models
Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ...
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September 10, 2020
Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When?
Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ...
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July 23, 2020
Digital Pathology
Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology.
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June 11, 2020
DNA Damage Response (DDR)
Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer ...
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April 22, 2020
The Role of Proteomics in Oncology Biomarker Discovery
Explore the evolving role of proteomics in oncology biomarker discovery, specifically identifying and analyzing biomarkers in cancer drug development.
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March 6, 2020
How to Develop Predictive Cancer Biomarkers
How to develop predictive cancer biomarkers: Explore the different types and classes of cancer biomarker, and the key ...
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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November 5, 2019
Cancer Biomarkers: Improving Detection and Treatment
Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and ...
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September 17, 2019
Targeting Tumor-Associated Antigens and Tumor-Specific Antigens
Learn more about targeting human tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs) in immunotherapy development, including therapeutic approaches and preclinical models for assessing TSA/TAA targeting agents.
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August 20, 2019
Circulating Tumor Cells in Preclinical Mouse Models of Metastasis
Explore the utility of preclinical mouse models of metastasis to study circulating tumor cells (CTCs) and the ...
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July 19, 2019
Recapitulating Clinical Metastatic Events in Preclinical Mouse Models
Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process.
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May 30, 2019
Key Differences between hPBMC and hCD34 Humanized Mouse Models
Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the ...
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March 7, 2019
Genetic Abnormality Spectrum in Hematologic Cancers
What have we learned about the genetics of hematological cancers, and how can that be modelled for research and drug ...
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