April 1, 2021
Expanding the Horizon of Antibody-Drug Conjugates for Cancer Treatment
This post explores the fast-expanding topic of antibody-drug conjugates (ADCs), including those that have been approved to date and recent and future innovations that may come to bear on ADCs.
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December 16, 2020
Germ-Free or Antibiotic-Treated Mice? Which Model for Studying the Role of the Gut Microbiota in Preclinical Studies
Explore the differences and similarities of germ-free (GF) and antibiotic-treated mice as models for studying the role ...
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November 10, 2020
SHP2 and SOS1 Targets: Additional Players in the KRAS Inhibitors Race?
Explore why upstream KRAS-mutant targets, such as SHP2 and SOS1, may lead to optimized therapeutic combinations for ...
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October 14, 2020
Evaluating Immunotherapy Mechanism of Action with Immune Cell Lineage-Specific DTR Models
Explore how transgenic diphtheria toxin receptor (DTR) preclinical models are used to better understand immunotherapy ...
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September 10, 2020
Genome-Wide RNAseq and Array-Based NanoString Transcriptomic Technologies: Which To Use and When?
Compare the pros and cons of two widely used transcriptomic technologies - genome-wide RNAseq and array-based ...
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July 23, 2020
Digital Pathology
Explore digital pathology, and how it‘s being used for biomarker discovery particularly within immuno-oncology.
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June 11, 2020
DNA Damage Response (DDR)
Explore how various cellular DNA damage response (DDR) and DNA repair pathways are targeted to develop novel anticancer therapeutic strategies.
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April 22, 2020
The Role of Proteomics in Oncology Biomarker Discovery
Explore the evolving role of proteomics in oncology biomarker discovery, specifically identifying and analyzing ...
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March 6, 2020
How to Develop Predictive Cancer Biomarkers
How to develop predictive cancer biomarkers: Explore the different types and classes of cancer biomarker, and the key ...
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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November 5, 2019
Cancer Biomarkers: Improving Detection and Treatment
Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and guiding treatment decisions. Review the vast array of biomolecules which act as cancer biomarkers, including genetic, transcriptomic, epigenetic, proteomic, and metabolomic biomarkers.
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September 17, 2019
Targeting Tumor-Associated Antigens and Tumor-Specific Antigens
Learn more about targeting human tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs) in immunotherapy ...
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August 20, 2019
Circulating Tumor Cells in Preclinical Mouse Models of Metastasis
Explore the utility of preclinical mouse models of metastasis to study circulating tumor cells (CTCs) and the ...
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July 19, 2019
Recapitulating Clinical Metastatic Events in Preclinical Mouse Models
Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process.
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May 30, 2019
Key Differences between hPBMC and hCD34 Humanized Mouse Models
Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the ...
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