Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

December 3, 2020 The Latest Developments on PARP Inhibitors for Prostate Cancer Treatment Review the status of PARP inhibitors (PARPi) for prostate cancer treatment, with a focus on recent developments in drug approvals and published data. LEARN MORE
October 26, 2020 Applications and Benefits of Engineered Syngeneic Cell Lines Explore the use and main benefits of engineered syngeneic cell lines for investigating drug targets and biological ... LEARN MORE
July 10, 2020 Immunogenomics in Oncology Drug Development Explore the emerging field of immunogenomics and how it’s being used to answer key questions related to immunotherapy ... LEARN MORE
April 28, 2020 PARP Inhibitors: Where Are We in 2020 and What’s Coming Next? Review the current approval status of PARP inhibitors, and what could be coming next for this class of agent, including ... LEARN MORE
February 13, 2020 Targeting KRAS: Finally Drugging the Undruggable? Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent ... LEARN MORE
November 22, 2019 The Importance of Companion Diagnostics Explore the importance of companion diagnostics (CDx) and the benefits of their early adoption and drug codevelopment. LEARN MORE
October 4, 2019 What are PDX-Derived Organoids (PDXOs)? Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models. LEARN MORE
September 19, 2019 Key Discoveries in the Development of Modern HUB Organoids Learn about the key research discoveries leading to the development of modern HUB Organoids. LEARN MORE
August 29, 2019 Key Applications of Organoids Explore the key applications of organoids, which are increasingly being used as in vitro models of human development ... LEARN MORE
August 22, 2019 How Do HUB Organoids Differ from Other Organoid Cultures? Explore the similarities and differences between the Hubrecht Organoid Technology (HUB) approach and other commonly ... LEARN MORE
August 15, 2019 How are Organoids Different from Spheroids? Explore the similarities and differences between organoids and spheroids - the most commonly used approaches for establishing 3D cell culture systems. LEARN MORE
August 8, 2019 The Development of HUB Organoids Review the development and use of HUB Organoids, from the first discovery of Lgr5 as an adult stem cell biomarker in ... LEARN MORE
July 18, 2019 Tumor Organoids and the HUB Protocol Method Review organoid culture techniques and applications, with a focus on tumor organoids developed via HUB protocols. LEARN MORE