Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD


The early detection and correct diagnosis of cancer is important to optimize treatment regimens, and to give patients the best chance of response and survival. Diagnosis of ovarian cancer is often difficult, as is correctly staging the disease, which can lead to patients not receiving the best treatment for their cancer type. A new test hopes to better identify the exact stage of ovarian cancer, and help each patient receive the best tailored care for their disease.

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Patient participation in oncology clinical trials is very low due to patient concerns including worries over experimental drug effectiveness and uncertainty around joining clinical trials versus using a standard therapy. New methods are needed to encourage higher enrolment, one of which is ‘window of opportunity trials’ which use gaps in early standard of care treatment regimens to trial novel anticancer agents.

Data collected from human clinical trials are the critical part of approval of new drugs in all therapeutic areas including oncology. Unfortunately, the number of adults who take part in trials for novel oncology agents is very low. Statistics from the UK 10 years ago showed that...

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Targeted therapies can often be used in multiple different cancer types, dependent on multiple cancers all having the same target, such as an upregulated or overexpressed protein, or all having the same mutation. One example of this is VEGF and VEGF receptor (VEGFR) inhibitors, which act as antiangiogenic agents and block the formation of new blood vessels to tumors in a range of VEGF expressing cancer types. It was originally thought that angiogenesis inhibitors could be a magic bullet applicable in many cancer types, but now in practice it has been shown that these agents have limitations. As a new VEGFR inhibitor reaches the market, we take a look at the ups and downs of its...

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Type 1 diabetes has recently been the focus of forward thinking research, embracing technological and scientific advances to find new and innovative treatment options. Now, stem cell research has taken the first steps toward finding a potential cure for this chronic and life-altering disease.

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