Blog

Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD

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The obesity epidemic and a progressively more sedentary lifestyle have contributed to type 2 diabetes (T2D) becoming increasingly more common. Cardiovascular (CV) disease is the major cause of mortality among patients with T2D, accounting for 60–80% of deaths in these patients. Despite recent studies demonstrating the benefit of a proper glycemic control in decreasing cardiovascular risk in T2D, there have been lingering concerns about potential adverse cardiovascular effects of some anti-diabetes medications. Eli Lilly and Boehringer Ingelheim have announced that their diabetes medication Jardiance is the first of its kind to reduce the risk of heart attacks, strokes and other...

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Ovarian cancer is the fifth most common cancer in women. Worldwide, nearly 239,000 women were diagnosed with ovarian cancer in 2012, with variable incidence rates in different countries. Ovarian cancer becomes more common after menopause; nevertheless the occurrence of ovarian cancer in younger women has increased by 56% in the last 50 years. Early diagnosis is key to manage the disease, however early ovarian cancer symptoms are often neglected. New treatment options are needed for patients with advanced or recurring disease. Phase I/II studies are evaluating the safety and efficacy of a new combination therapy approach for patients whose disease has relapsed.

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Checkpoint inhibitors are the most heralded drugs in oncology. They work by removing the brake on the immune system to promote its activation. In other words they block the molecules that switch off immune cells. However the early results of a recent Phase I study sponsored by Pfizer revamped some interest around therapies that take the opposite approach: keep the activating receptor on the immune cells constantly switched on.

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Breast cancer is the most frequently diagnosed cancer type and the second leading cause of cancer death in women worldwide. Triple negative breast cancer (TNBC), the most aggressive form of the disease, accounts for 10-20% of all breast cancer cases and cannot be treated with some of the most effective targeted therapies available for other breast cancer cases. A new study has identified a biomarker that could be utilized to develop personalized therapies for TNBC patients.

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