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Melanoma accounts for approximately five percent of all skin cancer cases, yet it is responsible for nearly 75 percent of skin cancer-related deaths. The BRAF gene is frequently mutated in melanoma, leading to aberrant activation of an important growth pathway. Melanoma patients who receive treatment with targeted therapies that inhibit activated BRAF experience an initial response, but quickly relapse as their cancers find alternative pathways to grow and spread. Researchers at The Wistar Institute studied melanoma “escape routes” in the hope of finding combination treatments that prompt them to die. Their findings were published by the journal Clinical Cancer Research.

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