Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology and CVMD


Cancer cells have the ability to evade the immune system by exploiting a self-regulatory mechanism that immune cells use to avoid attacking healthy cells. Luckily we now understand how to therapeutically reverse this immune escape, and researchers have developed innovative antibodies that target the inhibitors present on the tumor surface (e.g. anti-PD-1/PD-L1 or anti-CTLA-4). A new study in preclinical models has recently demonstrated that the conventional chemotherapeutic cyclophosphamide can be efficacious as an anticancer agent if used in combination with immunostimulatory Toll-like receptor agonists.

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Obesity was classified as a disease by the American Medical Association in 2013, and has become a serious epidemic issue in many developed and developing countries. Global obesity levels have more than doubled since 1980, with more than 600 million adults classified as obese in 2014. It is commonly believed that carrying excessive body fat would help in isolating the body from low external temperatures. Understanding how body fat works to keep animals warm is particularly important for obesity researchers. A recent paper published in the American Journal of Physiology - Endocrinology and Metabolism is now challenging the common belief, showing that in preclinical models fur, rather than...

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Human cancer cell lines are a powerful model system that can be propagated virtually indefinitely in culture, and manipulated to assess sensitivity to anticancer drugs or to investigate the molecular factors behind response to therapy. Oncology research using cancer cell lines has provided meaningful insights into many aspects of cancer susceptibility to treatment and into the role of specific genes in this process. More recently key genomic alterations and gene expression analysis of cultured cancer cells has helped pathologists to perform more accurate diagnoses. CrownBio has established a large collection of human tumor cell lines corresponding to a wide variety of tumor types, and...

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