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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Revolutionizing Cancer Drug Combination Discovery with AI: Introducing SynAI

I am excited to share with you a significant advancement in the field of cancer research, the culmination of recent efforts by my team and me. We have published our study on "SynAI" in the journal "Bioinformatics Advances" (November 2023). SynAI is an AI-driven platform designed to predict the synergistic effects of cancer drug combinations, poised to fundamentally change how we discover and evaluate cancer treatments.

Understanding SynAI: A Major Leap in Cancer Treatment

At its heart, SynAI is about predicting the combined effects of cancer drugs, known as drug synergism. This AI-driven solution is flexible and innovative, focusing on early-stage drug discovery to identify the therapeutic potential of various compound combinations.

Unlike traditional approaches, SynAI does not rely on actual drug combinations or specific cell lines. Instead, it utilizes the Simplified Molecular Input Line Entry System (SMILES) sequences of compounds. Our AI model, trained with over 1.2 million in vitro tests across different cancer cell lines, predicts potential synergisms or antagonisms between drug combinations without the need for costly and time-consuming physical synthesis or structural analysis.

Figure 1. Samples of the SynAI interface, where you can select the target cell
line and the drug combination of interest for drug synergy prediction.

How SynAI Benefits Cancer Research

  • Cost-efficiency: By using only SMILES sequences, SynAI significantly reduces the costs associated with candidate screening during drug development.
  • Time-saving: The computational predictions eliminate the need for physical compound synthesis, speeding up the initial screening process.
  • Flexibility and Adaptability: Our AI model is retrainable, meaning it can continuously adapt and improve with new data, making it a future-proof tool in the battle against cancer.

SynAI's Unique Features

  • Multi-input Modes: SynAI offers four input modes to cater to different research needs and allows for bulk processing through an API.
  • Robust AI Core: The platform’s AI core, built on a multi-layer perceptron network, has undergone rigorous training and testing.
  • Predictive Accuracy: Our model uniquely handles SMILES sequences, ensuring accurate predictions regardless of the compound order.
  • Retrainable and Adaptive AI Core: SynAI's AI core is not static; it's retrainable and adaptive. This means that any new experimental data can be seamlessly integrated into the core to reinforce prediction coverage and enhance accuracy over time. This dynamic feature ensures that SynAI continuously improves its performance as more data becomes available, making it a powerful tool for cutting-edge research.

The Future of Personalized Medicine

The potential of SynAI extends beyond its current applications. We plan to incorporate organoid and clinical data, paving the way for personalized medicine. Imagine a future where cancer treatment is tailored to the individual, maximizing therapeutic efficiency and minimizing side effects.

Conclusion: A Step Towards a Brighter Future

In conclusion, SynAI stands out not only for its current capabilities but also for its potential to evolve with ongoing research. It's more than a platform; it's a beacon of hope in our continuous fight against cancer.

CrownSyn™ Drug combination Analysis Service Image
SynAI: An AI-driven Cancer Drugs Synergism Prediction Platform Image
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