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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Tissue

Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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KRAS

Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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EGFR

Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Bioinformatics

Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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CRISPR/Cas9

Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Genomics

Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Screens

Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Toxicology

Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Resources

Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Blogs

Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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Navigating Organoid Research: FAQs and Expert Guidance

What types of organoid models are available for me in the Crown Bioscience biobank?

Our biobank offers over 200 patient-derived organoid (PDO) models for six oncological indications. Additionally, we have patient-matched normal models available for four indications, as well as patient-matched primary and metastatic models. Furthermore, we provide irritable bowel disease (IBD) PDO models for testing anti-inflammatory treatments and regenerative medicine approaches.

Are there PDX-Derived Organoid (PDXO) models available?

Yes, we generate PDXO models using our extensive patient-derived xenograft (PDX) biobank. Currently, we have around 400 PDXO models available from 18 indications, and our selection is continuously expanding. Additionally, we provide in vivo models that match the PDXO models for validation or efficacy studies.

What advantages do your PDO and PDXO models offer?

Our PDO and PDXO models have preserved genetic backgrounds and gene expressions compared to their parental models. They show high correlations over passaging, ensuring consistency and reliability of data. These models exhibit similar responses to pharmacological profiling as their in vivo counterparts, making them highly predictive for drug responses.

How does Crown Bioscience ensure the quality and reliability of their organoid models?

Authentication analyses are conducted to ensure the absence of genetic drift and contamination, ensuring that historical data from primary tissues are comparable. We verify the preservation of genetic background and gene expression in our PDXO models, and we have found that the responses between in vitro and in vivo models during pharmacological profiling are similar. Following standard procedures for organoid culture, including careful passaging and freezing methods, is crucial for maintaining long-term and high-quality cultures.

What services does Crown Bioscience offer in relation to organoids?

As a Contract Research Organization (CRO), we provide in vitro, in vivo, and biomarker analysis services. Organoids can be used for early-stage drug discovery, conducting high-throughput screens of thousands of compounds. Additionally, they are utilized in the drug development stage to test lead compounds for efficacy, safety, side effects, combinatorial effects, and pharmacokinetics. The high predictivity of organoids in drug response allows for in vitro clinical trials and downstream biomarker analysis, enabling the identification of responsive and non-responsive patient populations.

What advancements can I expect in Crown Bioscience's organoid capabilities?

We are planning to release large panel screening capabilities in the third quarter of this year. This will involve the use of organoids from different indications with various backgrounds.

How will Crown Bioscience accelerate my research timelines and reduce costs?

Our upcoming release of large panel screening capabilities using organoids from different indications will fast-track research activities by shortening timelines and reducing costs. These capabilities will enable you to efficiently screen a wide range of compounds and make informed decisions about lead compounds.

Can Crown Bioscience provide additional support for my complex research applications?

Sure, we offer co-culturing assays with immune and stromal cells to extend the applications of organoid models. We currently provide several well-characterized co-culture assays and plan to further expand the co-culture complexity in the near future. The use of CRISPR/Cas technology enables the development of knock-down, knock-out, and knock-in models for specific applications.

Can I visualize and quantify complex morphology and biological changes in organoid models?

Certainly! We employ high-content imaging technology, enabling visualization and quantification of complex morphological and biological changes in organoids. This provides a deeper understanding of the models and facilitates comprehensive analyses.

How will working with Crown Bioscience contribute to personalized medicine research?

Organoids are highly predictive and reproducible in vitro models, poised to revolutionize research in the field of personalized medicine. Crown Bioscience's organoid models allow for the identification of patient populations, facilitating personalized treatment approaches.

Visit OrganoidBase™ to leverage the power of organoids and advance your research towards improving patient outcomes.


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