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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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The Importance of Licensed Cell Lines for Cancer Research

The Importance of Licensed Cell Lines for Cancer Research

This post delves into some frequently asked questions about OmniScreenand its unique capabilities in providing compliant, large-scale cell line screening solutions that are not only cutting-edge but also aligned with industry standards and regulations. Whether you're a researcher, a biotech professional, or someone keen on understanding the nuances of cell line screening, this discussion will provide valuable insights into how Crown Bioscience can support your scientific endeavors.

1. What sets Crown Bioscience apart in its cell line screening services?

Crown Bioscience excels in providing nearly 900 commercially licensed cell lines, ensuring intellectual property (IP) compliance and top-tier quality for robust oncology research across over 30 cancer indications.

2. How do licensed cell lines enhance Crown Bioscience's cell panel screenings?

Licensed cell lines offer reliable and well-characterized options for cell panel screenings to ensure that Crown and our clients are not violating the IP of any of the providers of those lines. This assures consistent, high-quality, and legally compliant resources for translational research, pivotal in bridging in vitro findings with in vivo applications.

3. In what ways does cell line licensing affect the quality of research?

Licensing provides Crown with the freedom to operate our service business without risk of IP infringement , thus bolstering the credibility of research results. Using licensed cell lines mitigates the risk of illegally obtained results, which is crucial for translational and clinical research success.

4. What is the significance of Crown Bioscience’s ability to provide simple solutions for non-licensable cell lines?

Offering simple solutions for non-licensable cell lines ensures that researchers have access to necessary genetic materials, even when traditional licensing isn't possible. This inclusivity supports a wider range of research possibilities and promotes the progression of scientific inquiry without legal constraints.

5. Can licensed cell lines impact the cost-effectiveness of research?

While licensing fees may initially increase costs, the long-term benefits include reduced rework due to reliable quality, aiding in more efficient drug development processes and potentially lowering overall R&D expenditures.

6. What advantage does Crown Bioscience's licensed cell line screening offer in terms of real-world clinical relevance?

Through Crown Bioscience's OmniScreen service, licensed cell lines—matched with in vivo models—ensure that screening results are legally compliant and clinically relevant, enabling more informed predictions and accelerated transition from bench to bedside.

7. Why is licensing important for research funding and publication?

Using licensed cell lines demonstrates a commitment to quality and legal compliance, significantly enhancing the integrity and publishability of research, while also strengthening grant and funding proposals.

8. What advantages do made-to-order cell panel screening services provide?

Made-to-order cell panel screening services like OmniScreen allow for high customization to meet the unique demands of each research project. Tailoring the cell panels to the specific requirements of the study can lead to more accurate and relevant results, driving efficient drug discovery and development processes.

Discover how OmniScreen can transform your research and lead you to groundbreaking discoveries. Let’s innovate together. Contact us to learn more or to schedule a consultation.

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