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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Biomarkers and Bioanalysis

Leverage our global labs and 150+ scientists for fast, tailored project execution. Benefit from our expertise, cutting-edge tech, and validated workflows for reliable data outcomes.

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Data Science and Bioinformatics

Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Drug Resistance

Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Patient Tissue

Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Biomarker Analysis

Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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In Vitro High Content Imaging

Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Mass Spectrometry-based Proteomics

Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Ex Vivo Patient Tissue

Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Spatial Multi-Omics Analysis

Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Biomarker Discovery

De-risk your drug development with early identification of candidate biomarkers and utilize our biomarker discovery services to optimize clinical trial design.

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DMPK Services

Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Efficacy Testing

Explore how the novel HuGEMM™ and HuCELL™ platforms can assess the efficacy of your molecule and accelerate your immuno-oncology drug discovery programs.

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Laboratory Services

Employ cutting-edge multi-omics methods to obtain accurate and comprehensive data for optimal data-based decisions.

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Pharmacology & Bioanalytical Services

Leverage our suite of structural biology services including, recombinant protein expression and protein crystallography, and target validation services including RNAi.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Carry out safety pharmacology studies as standalone assessments or embedded within our overall toxicological profiling to assess cardiovascular, metabolic and renal/urinary systems.

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Our Company

Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Our Purpose

Learn more about the impact we make through our scientific talent, high-quality standards, and innovation.

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Our Responsibility

We build a sustainable future by supporting employee growth, fostering leadership, and exceeding customer needs. Our values focus on innovation, social responsibility, and community well-being.

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Meet Our Leadership Team

We build a sustainable future by fostering leadership, employee growth, and exceeding customer needs with innovation and social responsibility.

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Scientific Advisory Board

Our Scientific Advisory Board of experts shapes our strategy and ensures top scientific standards in research and development.

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News & Events

Stay updated with Crown Bioscience's latest news, achievements, and announcements. Check our schedule for upcoming events and plan your visit.

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Career Opportunities

Join us for a fast-paced career addressing life science needs with innovative technologies. Thrive in a respectful, growth-focused environment.

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Scientific Publications

Access our latest scientific research and peer-reviewed articles. Discover cutting-edge findings and insights driving innovation and excellence in bioscience.

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Discover valuable insights and curated materials to support your R&D efforts. Explore the latest trends, innovations, and expertly curated content in bioscience.

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Explore our blogs for the latest insights, research breakthroughs, and industry trends. Stay educated with expert perspectives and in-depth articles driving innovation in bioscience.

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5 Criteria for Choosing a Contract Research Organization

How to choose a contract research organization, main CRO features including experience, quality, and capabilitiesContract research organizations (CROs) vary in capability, quality, experience, cost, and ease of collaboration. Weigh these five criteria to determine if a CRO is a good fit for your specific project.

Choosing a Contract Research Organization

Now more than ever, pharma companies are required to do more with fewer internal resources and in less time. Outsourcing certain functions to specialized CROs helps pharma researchers stretch their resources and provides biotech start-ups with access to otherwise capital-intensive capabilities.

You need to apply the same diligence in choosing a CRO that you would in choosing a new employee. This includes considering if they’ll make the right contribution and if the CRO is a “good fit”. Here are the five criteria to consider when determining which is the best CRO for your research programs.

What are the Contract Research Organizations Capabilities?

Does the CRO provide the service you need?

This seems like a basic question, but many companies overlook it. You need to ensure that the CRO is capable of meeting the technical demands of your study, and that their methods are validated. Validation needs to go beyond “we’ve done this type of study once and it looked good”.

Also make sure that the capabilities at one site are identical to the other sites that offer it. This tells you about how the CRO cross-fosters best practices.

What is the CRO’s QA Process?

While you may find a few CROs with the right capabilities, they may not all produce high quality work. Any data you get from a CRO should be the same high quality that you would expect from in-house studies

Make sure that the CRO has a process that provides quality assurance (QA) and monitoring, and that it’s directly linked to compliance with regulations. Review the quality certificates that the CRO claims to hold, and review their processes.

If a CRO does not have a QA management system in place, ask why, and also potentially think about choosing a different vendor who does have a reliable and practiced system.

How Much Experience Does the CRO Have?

With quality comes experience. Not the other way around. Just because a team of experienced staff technicians will be running your ELISA does not mean it will be high-quality. You should always insist on seeing the credentials of the project team being proposed to ensure they have experience in your therapeutic area and have run the study type you need multiple (successful) times.

Also, never hesitate to ask for a client reference list. It should raise a red flag if any CRO tells you their references are confidential. A CRO with an excellent reputation will always be happy to provide at least one or two references.

How Much Does Contract Research Outsourcing Cost?

Have you ever calculated how much your company saves per hour by utilizing a fee-for-service organization? The savings can be enormous. But buyer beware: The saying “You get what you pay for” is often true when choosing a CRO.

When comparing different quotes/bids, be aware of unit costs/line items and not just total cost. While low-cost proposals are often attractive, it may not account for all study specifications and may lead to higher unexpected costs down the road.

Flexible payments built on milestones may also be important. For instance, imagine you’re running a twenty-week efficacy study in a very expensive rat model but early data is disappointing. Do you have to pay for the entire study if you choose to end it at 10 weeks? For cases like these, the devil is in the details and you should be sure to build in such milestones should your studies warrant them.

Does the CRO Communicate and Maintain Relationships Well?

These two factors are interrelated and equally important. All operations within the CRO, whether procurement, business development or research operations, should be transparent and linked with each other, preventing duplicate activities and miscommunications. This avoids study meetings where CRO team members don’t know key study points.

Teams change, and people leave positions; however, if your study is or will be impacted by the change in staff or technicians, you may want to reconsider the relationship. Consistency is a very good thing for a CRO/client relationship and successful study outcomes.


These are just a few of the things to consider when choosing a “good fit” CRO. Every need is different and these guiding five criteria will go a long way toward narrowing your search down to two or three finalists. You then need to exercise care and attention in your final selection and not just take the lowest bid -- paying a little more for the service, quality, and experience you need is often the way to go.

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