August 24, 2017Mouse Allograft Models: A GEMM-Derived Efficacy Testing Platform
Genetically engineered mouse models (GEMM) were reviewed in a recent post, as immunocompetent, murine immunity models for immuno-oncology assays. While highly useful for monitoring cancer progression and mechanism of action studies, the spontaneous nature of GEMM tumors makes them complex and costly models for efficacy studies.
August 8, 2017Syngeneic Tumor Mouse Models: The Pros and Cons
Immunotherapeutics are bringing remarkable survival rates for certain cancer patients, but they are also bringing some remarkable challenges for oncology drug developers. Evaluating immunomodulatory agents is more complex than assessing “common” chemotherapeutics or targeted agents. It requires preclinical models with an intact immune system (or at least ...