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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology

October 4, 2019 What are PDX-Derived Organoids (PDXOs)? Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models. LEARN MORE
September 19, 2019 Key Discoveries in the Development of Modern HUB Organoids Learn about the key research discoveries leading to the development of modern HUB Organoids. LEARN MORE
September 17, 2019 Targeting Tumor-Associated Antigens and Tumor-Specific Antigens Learn more about targeting human tumor-associated antigens (TAAs) or tumor-specific antigens (TSAs) in immunotherapy ... LEARN MORE
September 13, 2019 HUB Tumor Organoids: Top 15 Questions Review the key questions on HUB tumor organoids from our recent webinar, answered by Dr Sylvia Boj, Hubrecht Organoid ... LEARN MORE
September 11, 2019 HUB Organoids: Top 9 Technical Questions Review the top 9 technical questions on HUB organoid development from our recent webinar, answered by Dr Sylvia Boj, ... LEARN MORE
September 10, 2019 How to Assess Immunotherapy Toxicity with NHP Models How to Assess Immunotherapy Toxicity with NHP Models Explore non-GLP exploratory toxicology NHP studies as a rapid and ... LEARN MORE
August 29, 2019 Key Applications of Organoids Explore the key applications of organoids, which are increasingly being used as in vitro models of human development and diseases, such as cancer. LEARN MORE
August 22, 2019 How Do HUB Organoids Differ from Other Organoid Cultures? Explore the similarities and differences between the Hubrecht Organoid Technology (HUB) approach and other commonly ... LEARN MORE
August 20, 2019 Circulating Tumor Cells in Preclinical Mouse Models of Metastasis Explore the utility of preclinical mouse models of metastasis to study circulating tumor cells (CTCs) and the ... LEARN MORE
August 15, 2019 How are Organoids Different from Spheroids? Explore the similarities and differences between organoids and spheroids - the most commonly used approaches for ... LEARN MORE
August 8, 2019 The Development of HUB Organoids Review the development and use of HUB Organoids, from the first discovery of Lgr5 as an adult stem cell biomarker in the Clevers lab, to the model features and data which have led to their widespread use today. LEARN MORE
July 26, 2019 Targeting the CD47/SIRPɑ Axis in Cancer Immunotherapy Explore why the CD47/SIRPα axis is an important immuno-oncology target and the methods being used to block this axis. LEARN MORE
July 19, 2019 Recapitulating Clinical Metastatic Events in Preclinical Mouse Models Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process. LEARN MORE
July 18, 2019 Tumor Organoids and the HUB Protocol Method Review organoid culture techniques and applications, with a focus on tumor organoids developed via HUB protocols. LEARN MORE
July 9, 2019 CAR-T Cell Therapy for Pancreatic Cancer Explore how CAR-T cell therapy is showing promise as a novel treatment strategy for pancreatic cancer. LEARN MORE