Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology

February 16, 2018 3 Key Uses for Humanized Mouse Models We’ve been focusing on humanized mouse models recently on our blog, from evolution of immunodeficient host mice through to the development of derivative hPBMC and hCD34+ HSC humanized mice. This post now takes a look at how you can combine humanized mice with human tumors for three key uses in assessing human-specific immunotherapeutics. LEARN MORE
January 30, 2018 Humanized Mouse Model Head to Head: hPBMC vs hCD34+ The future of cancer treatment is often considered to be combination regimens (dual immunotherapeutics or ... LEARN MORE
January 26, 2018 Comparison Guide: huNOG® & huNSG™ Humanized Models Previously our blog posts have reviewed humanized mice, looking at hPBMC vs hCD34+ models, how they differ, and how to ... LEARN MORE
January 5, 2018 2018 Technology Advances – Applying Next Generation Sequencing to Single Cell Analysis It is an axiom in biology that expression of genotype determines phenotype. This means, for the large part, that the ... LEARN MORE
December 19, 2017 2017 Review: Precision Medicine - From Traditional to Tailored Treatment With continued advances in technology, and the increasing focus on individualized therapy, the field of precision ... LEARN MORE
December 7, 2017 2017 Review: PARP Inhibitor Update and Approvals As the holiday season approaches, CrownBio is celebrating with a look back over the important research and scientific ... LEARN MORE
December 1, 2017 Mouse Clinical Trials - The Power Behind Study Design: Top 10 Questions Mouse Clinical Trials (MCT) using patient-derived xenograft (PDX) models are a key preclinical tool for predicting drug effectiveness, targeting responder populations, and identifying biomarkers before you enter the clinic. MCTs are designed to enhance preclinical predictivity and help to reduce the current 95% attrition rate of oncology agents in clinical ... LEARN MORE
November 28, 2017 How Gut Bacteria Influence Cancer Treatment Efficacy Over the past few years, scientists have come to a deeper understanding of how microorganisms can be seen as a major ... LEARN MORE
November 20, 2017 Misidentified Cell Lines: The Scale of the Problem and How to Avoid It Cell lines have been the cornerstone of life science research for decades. Yet they’ve been misidentified and misused ... LEARN MORE
November 10, 2017 EORTC 2017 Short Talk Review Transcriptomic Analysis of Patient-Derived Xenografts Reveals Heterogeneity in Human and Mouse Stroma/Immune ... LEARN MORE
November 8, 2017 Humanized Mouse Clinical Trials for Immunotherapy Development Recent posts have covered the different types of mouse clinical trial (MCT) and which is most suited to any given drug development program. These posts all consider immunodeficient mice, and the progression of oncology agents such as targeted drugs or chemotherapy. However, MCT can also be used to progress immunotherapies, but require the use of humanized ... LEARN MORE
November 3, 2017 Using PDX as Surrogate Models for TME Investigation The diversity of cancers is due to the fact that there are numerous different types, along with many different ... LEARN MORE
October 31, 2017 How to Choose the Right Type of Mouse Clinical Trial As covered in our recent blog post, Mouse Clinical Trials using patient-derived xenograft (PDX) models provide more ... LEARN MORE
October 26, 2017 Post FDA Approval: CAR-T Therapy Key Facts A few weeks ago, the FDA issued a historic approval of the first cancer cell therapy using a chimeric antigen receptor ... LEARN MORE
October 24, 2017 Top 5 Reasons To Use Mouse Clinical Trials Preclinical oncology drug development needs new tools and approaches. Current methods result in 95% attrition rates for ... LEARN MORE