February 14, 2019
Designing HSC Humanized Model Efficacy Studies
Review some key considerations in humanized model study design for successful preclinical oncology research.
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February 12, 2019
Targeting the FGF/FGFR Signaling Axis with PDX Models
Discover the complex range of FGFR family aberrations in cancer and how PDX models are a powerful tool for assessing ...
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February 7, 2019
CD40: Targeting Co-Stimulatory Pathways for Cancer Immunotherapy
Explore the role of CD40 in cancer immunotherapy, including its background, functions, and why combination regimens may ...
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February 6, 2019
Target Engagement Studies with Syngeneic Tumor Models
Syngeneic tumor models are a rapid and high-throughput option for novel drug discovery. Here’s how to use them for ...
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February 5, 2019
Beginners Guide to PBMC Humanized Tumor Models
Discover PBMC-humanized tumor models for short-term immunotherapy assessment studies.
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January 31, 2019
How to Test Human-Specific Combination Immunotherapies In Vivo
Learn how to evaluate combinations of human-specific checkpoint inhibitors in vivo, with double knock-in humanized drug ...
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January 29, 2019
Using Syngeneic Tumor Models for POC Studies
Syngeneic tumor models are a predictive, high-throughput option for validating novel therapeutic approaches. Here’s how to use them for immuno-oncology agent proof of concept studies.
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January 24, 2019
Imaging Orthotopic Disease
Explore how preclinical imaging helps visualize disease grown at depth in an in vivo, orthotopic setting.
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January 22, 2019
Tumor Heterogeneity in Preclinical Oncology Models
Real tumors are complex and heterogeneous, which has long frustrated efforts to recapitulate the disease in a ...
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January 15, 2019
Preclinical Imaging of Non-Solid Tumors
Learn how preclinical imaging helps overcome the particular challenges associated with modeling leukemia and other ...
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January 8, 2019
RAS: Targeting the Impossible
Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical models available to test up-and-coming RAS targeted agents.
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December 20, 2018
Immunotherapy 2018 Review: From the Nobel Prize to Clinical Trial Failures
2018 has been a roller coaster year for immunotherapy, from exciting Nobel Prize news to warning IDO1 clinical trial ...
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December 18, 2018
3 Tips to Navigate a PDX Database
Find out how to select the right patient-derived xenograft model database for you, and which features to use for quick ...
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December 13, 2018
Obesity, Cancer Development, and Immunotherapy Response
How does obesity impact cancer development and immunotherapy response? Find out in our review of cutting-edge combined ...
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December 11, 2018
Preclinical Applications for Non-Invasive Imaging Technologies
In this introduction to preclinical imaging, we explore optical imaging technologies, such as bioluminescent and ...
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