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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology

February 14, 2019 Designing HSC Humanized Model Efficacy Studies Review some key considerations in humanized model study design for successful preclinical oncology research. LEARN MORE
February 12, 2019 Targeting the FGF/FGFR Signaling Axis with PDX Models Discover the complex range of FGFR family aberrations in cancer and how PDX models are a powerful tool for assessing ... LEARN MORE
February 7, 2019 CD40: Targeting Co-Stimulatory Pathways for Cancer Immunotherapy Explore the role of CD40 in cancer immunotherapy, including its background, functions, and why combination regimens may ... LEARN MORE
February 6, 2019 Target Engagement Studies with Syngeneic Tumor Models Syngeneic tumor models are a rapid and high-throughput option for novel drug discovery. Here’s how to use them for ... LEARN MORE
February 5, 2019 Beginners Guide to PBMC Humanized Tumor Models Discover PBMC-humanized tumor models for short-term immunotherapy assessment studies. LEARN MORE
January 31, 2019 How to Test Human-Specific Combination Immunotherapies In Vivo Learn how to evaluate combinations of human-specific checkpoint inhibitors in vivo, with double knock-in humanized drug ... LEARN MORE
January 29, 2019 Using Syngeneic Tumor Models for POC Studies Syngeneic tumor models are a predictive, high-throughput option for validating novel therapeutic approaches. Here’s how to use them for immuno-oncology agent proof of concept studies. LEARN MORE
January 24, 2019 Imaging Orthotopic Disease Explore how preclinical imaging helps visualize disease grown at depth in an in vivo, orthotopic setting. LEARN MORE
January 22, 2019 Tumor Heterogeneity in Preclinical Oncology Models Real tumors are complex and heterogeneous, which has long frustrated efforts to recapitulate the disease in a ... LEARN MORE
January 15, 2019 Preclinical Imaging of Non-Solid Tumors Learn how preclinical imaging helps overcome the particular challenges associated with modeling leukemia and other ... LEARN MORE
January 8, 2019 RAS: Targeting the Impossible Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical models available to test up-and-coming RAS targeted agents. LEARN MORE
December 20, 2018 Immunotherapy 2018 Review: From the Nobel Prize to Clinical Trial Failures 2018 has been a roller coaster year for immunotherapy, from exciting Nobel Prize news to warning IDO1 clinical trial ... LEARN MORE
December 18, 2018 3 Tips to Navigate a PDX Database Find out how to select the right patient-derived xenograft model database for you, and which features to use for quick ... LEARN MORE
December 13, 2018 Obesity, Cancer Development, and Immunotherapy Response How does obesity impact cancer development and immunotherapy response? Find out in our review of cutting-edge combined ... LEARN MORE
December 11, 2018 Preclinical Applications for Non-Invasive Imaging Technologies In this introduction to preclinical imaging, we explore optical imaging technologies, such as bioluminescent and ... LEARN MORE