Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology

December 13, 2018 Obesity, Cancer Development, and Immunotherapy Response How does obesity impact cancer development and immunotherapy response? Find out in our review of cutting-edge combined oncology and metabolic disease studies. LEARN MORE
December 11, 2018 Preclinical Applications for Non-Invasive Imaging Technologies In this introduction to preclinical imaging, we explore optical imaging technologies, such as bioluminescent and ... LEARN MORE
December 6, 2018 Exercise, Liver Cancer, and NAFLD Mortality Our current understanding of the mechanisms linking obesity and liver cancer is poor. Preclinical research links ... LEARN MORE
December 4, 2018 Preclinical Immunotherapy Safety and Toxicity Assessment While the overall objectives for preclinical evaluation of cancer immunotherapies are identical to other anticancer ... LEARN MORE
November 29, 2018 Where Do Organoids Fit in Preclinical Cancer Modeling? There’s a wide range of new preclinical cancer models being developed, each with their own strengths and best uses. ... LEARN MORE
November 22, 2018 Are Cancer Stem Cells a Prime Target for Therapy? Cancer stem cells (CSC) represent one of the most challenging targets for cancer therapy today. Here we review the ... LEARN MORE
November 15, 2018 Prostate Cancer PDX Models and Oncology Analysis Studies: ENA 2018 This week at ENA 2018, we’re presenting up to date research on our PDX models, including our newly developed prostate cancer PDX panel. We’re also presenting some systems biology results on tumor model and kidney cancer patient analysis. LEARN MORE
November 15, 2018 Murine Immuno-Oncology Models: ENA 2018 At ENA 2018 we’re presenting new data on our wide range of immuno-oncology (I/O) platforms, with four posters covering ... LEARN MORE
November 14, 2018 Humanized Immuno-Oncology Model Update: ENA 2018 This week, at ENA Dublin 2018, we’re presenting new data from our novel humanized in vivo preclinical platforms. This ... LEARN MORE
October 24, 2018 PDX Study Investigates Cetuximab for Esophageal Cancer Esophageal cancer patients lack targeted agent treatment options, leaving them with a poor prognosis ... LEARN MORE
October 16, 2018 Humanized Mouse Models for Immunotherapy Research Humanized mouse models simulate real patient responses for the evaluation of immunotherapeutic drug candidates. This supports more translatable preclinical immuno-oncology research with deeper insight into an agent’s likely performance in clinical trials. LEARN MORE
October 11, 2018 Tumor Homograft Model Generation: Dissociated Tumor Cells vs Tumor Fragments Novel murine immunocompetent models are needed to overcome issues with commonly used syngeneic tumor models and ... LEARN MORE
October 9, 2018 Why PDX Are Needed for Metastatic Breast Cancer Research Metastatic breast cancer is currently incurable, though preclinical research is ongoing. Generating new therapies for ... LEARN MORE
October 3, 2018 Oncolytic Viruses in Cancer Therapy While viral therapy has existed conceptually for some time, it has only recently gained traction as a promising ... LEARN MORE
September 13, 2018 CAR-T Cell Therapy for Solid Tumors CAR-T cell therapies are currently only approved for blood cancers, but new preclinical research shows promise in using ... LEARN MORE