December 13, 2018
Obesity, Cancer Development, and Immunotherapy Response
How does obesity impact cancer development and immunotherapy response? Find out in our review of cutting-edge combined oncology and metabolic disease studies.
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December 11, 2018
Preclinical Applications for Non-Invasive Imaging Technologies
In this introduction to preclinical imaging, we explore optical imaging technologies, such as bioluminescent and ...
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December 6, 2018
Exercise, Liver Cancer, and NAFLD Mortality
Our current understanding of the mechanisms linking obesity and liver cancer is poor. Preclinical research links ...
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December 4, 2018
Preclinical Immunotherapy Safety and Toxicity Assessment
While the overall objectives for preclinical evaluation of cancer immunotherapies are identical to other anticancer ...
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November 29, 2018
Where Do Organoids Fit in Preclinical Cancer Modeling?
There’s a wide range of new preclinical cancer models being developed, each with their own strengths and best uses. ...
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November 22, 2018
Are Cancer Stem Cells a Prime Target for Therapy?
Cancer stem cells (CSC) represent one of the most challenging targets for cancer therapy today. Here we review the ...
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November 15, 2018
Prostate Cancer PDX Models and Oncology Analysis Studies: ENA 2018
This week at ENA 2018, we’re presenting up to date research on our PDX models, including our newly developed prostate cancer PDX panel. We’re also presenting some systems biology results on tumor model and kidney cancer patient analysis.
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November 15, 2018
Murine Immuno-Oncology Models: ENA 2018
At ENA 2018 we’re presenting new data on our wide range of immuno-oncology (I/O) platforms, with four posters covering ...
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November 14, 2018
Humanized Immuno-Oncology Model Update: ENA 2018
This week, at ENA Dublin 2018, we’re presenting new data from our novel humanized in vivo preclinical platforms. This ...
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October 24, 2018
PDX Study Investigates Cetuximab for Esophageal Cancer
Esophageal cancer patients lack targeted agent treatment options, leaving them with a poor prognosis ...
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October 16, 2018
Humanized Mouse Models for Immunotherapy Research
Humanized mouse models simulate real patient responses for the evaluation of immunotherapeutic drug candidates. This supports more translatable preclinical immuno-oncology research with deeper insight into an agent’s likely performance in clinical trials.
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October 11, 2018
Tumor Homograft Model Generation: Dissociated Tumor Cells vs Tumor Fragments
Novel murine immunocompetent models are needed to overcome issues with commonly used syngeneic tumor models and ...
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October 9, 2018
Why PDX Are Needed for Metastatic Breast Cancer Research
Metastatic breast cancer is currently incurable, though preclinical research is ongoing. Generating new therapies for ...
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October 3, 2018
Oncolytic Viruses in Cancer Therapy
While viral therapy has existed conceptually for some time, it has only recently gained traction as a promising ...
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September 13, 2018
CAR-T Cell Therapy for Solid Tumors
CAR-T cell therapies are currently only approved for blood cancers, but new preclinical research shows promise in using ...
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