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Welcome to CrownBio’s Blog where we share our thoughts
on the latest trends and hot stories in Oncology

August 15, 2019 How are Organoids Different from Spheroids? Explore the similarities and differences between organoids and spheroids - the most commonly used approaches for establishing 3D cell culture systems. LEARN MORE
August 8, 2019 The Development of HUB Organoids Review the development and use of HUB Organoids, from the first discovery of Lgr5 as an adult stem cell biomarker in ... LEARN MORE
July 26, 2019 Targeting the CD47/SIRPɑ Axis in Cancer Immunotherapy Explore why the CD47/SIRPα axis is an important immuno-oncology target and the methods being used to block this axis. LEARN MORE
July 19, 2019 Recapitulating Clinical Metastatic Events in Preclinical Mouse Models Explore the preclinical mouse models that best recapitulate the progression of the clinical metastatic process. LEARN MORE
July 18, 2019 Tumor Organoids and the HUB Protocol Method Review organoid culture techniques and applications, with a focus on tumor organoids developed via HUB protocols. LEARN MORE
July 9, 2019 CAR-T Cell Therapy for Pancreatic Cancer Explore how CAR-T cell therapy is showing promise as a novel treatment strategy for pancreatic cancer. LEARN MORE
June 11, 2019 Orthotopic or Subcutaneous Tumor Homograft Models? When should you use either subcutaneous or orthotopic pancreatic cancer tumor homografts, and where do they best support your drug discovery workflow? LEARN MORE
May 30, 2019 Key Differences between hPBMC and hCD34 Humanized Mouse Models Learn more about the different human immune cell populations in PBMC and HSC-humanized mouse models, to help select the ... LEARN MORE
May 7, 2019 Combination Therapies and Tumor Homograft Models Learn more about using tumor homograft models to assess oncology combination regimens, including immunotherapies. LEARN MORE
April 25, 2019 Large-Scale Immunotherapy Screening: How and Why? Learn more about the need for large-scale cancer immunotherapy screens and the different immunocompetent models ... LEARN MORE
April 16, 2019 5 Criteria for Choosing a Contract Research Organization Contract research organizations (CROs) vary in capability, quality, experience, cost, and ease of collaboration. Weigh these five criteria to determine if a CRO is a good fit for your specific project. LEARN MORE
April 3, 2019 New Analysis, Model ID, and Modeling Technologies at AACR 2019 In Atlanta this week we’re presenting data on our new analysis platforms and preclinical technologies. This post recaps ... LEARN MORE
April 2, 2019 Syngeneic and Tumor Homograft Immuno-Oncology Models at AACR 2019 Recap all our AACR presentations on murine models including bioluminescent orthotopic syngeneic models, syngeneic model ... LEARN MORE
April 1, 2019 Humanized Model Update at AACR 2019 Review all the new data on our humanized target models for human-specific CD40 and combination regimen assessment, and ... LEARN MORE
April 1, 2019 AACR19 Analysis: PDX and PDX-Derived Organoid Models Review all the new data on patient-derived xenograft (PDX) models we’re presenting at AACR 2019 this week, including ... LEARN MORE