February 13, 2020
Targeting KRAS: Finally Drugging the Undruggable?
Targeting KRAS - As promising clinical trial data emerges for KRAS G12C inhibitors, we review the background, recent achievements, and potential future approaches to drugging the once “undruggable” KRAS target.
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February 11, 2020
huPBMC Humanized Mouse Models: De-Risking Graft versus Tumor (GvT) Effects Through a Co-Culture Donor Selection Assay
Explore how to use a donor selection assay to limit the chances of graft vs tumor (GvT) effects when using huPBMC ...
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February 7, 2020
Preclinical Biomarker Discovery: Top 17 Questions
Review key questions on preclinical biomarker discovery from our recent webinar, answered by Mike Batey.
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February 6, 2020
How to Use Mouse Clinical Trials to Reinterpret Clinical Results
Explore how to use mouse clinical trials and analysis by linear mixed models approaches to reinterpret clinical trial ...
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February 4, 2020
How to Quantify Drug Efficacy and Effects in Mouse Clinical Trials
Learn how to correctly quantify drug efficacy and effects in mouse clinical trials using a linear mixed models ...
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January 31, 2020
How to Optimize Mouse Clinical Trial Study Design
Learn how to optimize mouse clinical trial study design, including choosing how many PDX to use, via a linear mixed ...
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January 29, 2020
Mouse Clinical Trial Analysis
Explore the current methods of mouse clinical trial analysis, and how these are improved by using a linear mixed models approach.
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January 22, 2020
Cancer Cell Line Authentication
Review best practices in cancer cell line authentication, including a comparison of STR and SNP assays.
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January 16, 2020
How Are Organoids Different from 3D Primary Cell Cultures?
Explore the key differences between organoids and primary cells grown in 3D, from both healthy tissue and tumors.
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January 9, 2020
How to Use Tumor Organoids for Oncology Drug Screening
Review how, and why, to use tumor organoids in in vitro oncology drug screening programs.
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December 3, 2019
Top 12 Questions: Applications of PDXO
Review the top 12 questions on PDX-derived organoid (PDXO) utilities from our recent webinar, answered by Dr. Rajendra Kumari, Global Head of Scientific Communication.
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November 29, 2019
Patient Tumors, PDX, and PDXO: Model Correlation Q&A
At our recent webinar we discussed our innovative PDX-derived organoid (PDXO) in vitro platform. We received many ...
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November 26, 2019
Ask the Expert: Successfully Developing PDX-Derived Organoid (PDXO) Models
Review the key questions on the development of PDX-derived organoids (PDXO) from our recent webinar, answered by Dr. ...
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November 22, 2019
The Importance of Companion Diagnostics
Explore the importance of companion diagnostics (CDx) and the benefits of their early adoption and drug codevelopment.
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November 5, 2019
Cancer Biomarkers: Improving Detection and Treatment
Explore the three main types of cancer biomarkers and their main uses in cancer diagnosis, informing prognosis, and ...
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