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In Vitro

Boost oncology drug discovery with XenoBase®, featuring the largest cell line selection and exclusive 3D organoid models. Benefit from OrganoidXplore™ and OmniScreen™ for rapid, in-depth analysis.

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In Vivo

Enhance drug development with our validated in vivo models, in vitro/ex vivo assays, and in silico modeling. Tailored solutions to optimize your candidates.

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Experience ISO-certified biobanking quality. Access top biospecimens from a global clinical network, annotated by experts for precise research.

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Harness your data and discover biomarkers with our top bioinformatics expertise. Maximize data value and gain critical insights to accelerate drug discovery and elevate projects.

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Accelerate innovative cancer treatments with our advanced models and precise drug screening for KRAS mutations, efficiently turning insights into clinical breakthroughs.

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Advance translational pharmacology with our diverse pre-clinical models, robust assays, and data science-driven biomarker analysis, multi-omics, and spatial biology.

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Our suite integrates preclinical solutions, bioanalytical read-outs, and multi-omics to uncover drug resistance markers and expedite discovery with our unique four-step strategy.

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Enhance treatments with our human tumor and mouse models, including xenografts and organoids, for accurate cancer biology representation.

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Apply the most appropriate in silico framework to your pharmacology data or historical datasets to elevate your study design and analysis, and to improve your chances of clinical success.

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Integrate advanced statistics into your drug development projects to gain significant biological insight into your therapeutic candidate, with our expert team of bioinformaticians.

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Accelerate your discoveries with our reliable CRISPR solutions. Our global CRISPR licenses cover an integrated drug discovery platform for in vitro and in vivo efficacy studies.

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Rely on our experienced genomics services to deliver high quality, interpretable results using highly sensitive PCR-based, real-time PCR, and NGS technologies and advanced data analytics.

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Gain more insights into tumor growth and disease progression by leveraging our 2D and 3D fluorescence optical imaging.

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Next-generation ion mobility mass spectrometry (MS)-based proteomics services available globally to help meet your study needs.

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Gain better insight into the phenotypic response of your therapeutic candidate in organoids and ex vivo patient tissue.

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Certified CRO services with NanoString GeoMx Digital Spatial Profiling.

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Rapidly evaluate your molecule’s pharmaceutical and safety properties with our in vivo drug metabolism and pharmacokinetic (DMPK) services to select the most robust drug formulations.

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Find the most appropriate screen to accelerate your drug development: discover in vivo screens with MuScreen™ and in vitro cell line screening with OmniScreen™.

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Global CRO in California, USA offering preclinical and translational oncology platforms with high-quality in vivo, in vitro, and ex vivo models.

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Organ-on-a-Chip: The Future of Improved Drug Discovery?

I’m a firm believer in the use of animal models in medical research. This is so for many reasons. A chemist and mentor of mine once said “to truly do drug discovery you absolutely need a liver and circulatory system”.

For example, in oncology, a cancer isn’t merely a collection of cancer cells. It is a complex, albeit disorganized tissue, with many interacting cell types. I myself have witnessed the critical importance of the interactions between cancer cells and their surroundings, including endothelial cells, immune cells, and other supportive stromal cells. The activity of one drug program I worked on absolutely depended upon these complex interactions.

So, when I look to the burgeoning field of “organs-on-a-chip”, please humor me, I’m a bit skeptical. The development and functioning of an organ, any organ, is a truly astonishing feat of biology – biology with a capital “B”. To me, this process is so astounding that I challenge the hubris in that we think we can recapitulate even a fraction of this, ex vivo and on a fabricated chip.

And yet, as I explore this field, I find myself amazed.

Organ-on-a- Chip Technology Captures the Mechanical Features that Cells Experience

At the interface of materials, microfluidics, and cell biology, organ-on-a-chip technology aims to recapitulate many of the features of the organs of the body that cannot be captured in standard two-dimensional, monolayer tissue culture. It may be surprising to learn, but the chief feature that organ-on-a-chip technology captures is the mechanical features that cells in organs experience.

Flow and shear stress experienced by endothelial cells, expansion and contraction of airways experienced by lung epithelium, and wave like peristaltic motion experienced by intestinal epithelium are all sources of fundamental signals that define and shape the cells of these organs. Under these conditions in a chip format, for instance, lung epithelia produce mucus and develop cilia, which beat in a uniform direction.

I encourage all of you reading this to watch the following video of a lecture given by Donald Ingber, a pioneer not only in the area of organ-on-a-chip technology, but someone who has spent the better part of their career understanding the mechanical features of biology.

Multitude of Applications to Drug Development including Immuno-Oncology

It isn’t too hard to imagine the multitude of applications of an ex vivo technology that better recapitulates cell biology at the organ level. Delivering drugs to the CNS is made challenging by the blood-brain-barrier. Better models of this structure will lead to better CNS drugs.

The ability to peer into the spatial and temporal interplay of cancer cells and immune cells, with clear resolution, will potentially help us understand phenomena such as T cell exhaustion. This in turn will potentially lead to a better understanding of therapeutic response heterogeneity in the immuno-oncology clinic.

New Technology to Minimize Animal Model Use

One further benefit to the continued development of this technology is the minimization of the use of animals in medical research. While I believe that “you need a liver and circulatory system to do drug discovery” that doesn’t necessarily mean the liver and circulatory system actually have to be attached to an animal.

Future Prospects for Improving Drug Development

If you watched the video, you will have noted that Dr. Ingber strongly feels that the current drug development model is “broken”. The fact is drug development is difficult. While it is true that sometimes models do not predict clinical outcomes, sometimes they do.

With continued advances in models of disease – for instance, the use of PDX in vivo oncology models or the continued exploration of organ-on-a-chip technology – drug developers will be better armed with the tools to make more informed decisions leading to improved translational fidelity.

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